López-Zamora Miguel, Cano-Villagrasa Alejandro, Cortés-Ramos Antonio, Porcar-Gozalbo Nadia
Department of Developmental and Educational Psychology, University of Malaga, 29010 Malaga, Spain.
Faculty of Health Sciences, Universidad Internacional de Valencia, 46002 Valencia, Spain.
Eur J Investig Health Psychol Educ. 2023 Oct 27;13(11):2358-2372. doi: 10.3390/ejihpe13110166.
Autism Spectrum Disorder (ASD) and epilepsy are increasingly prevalent comorbidities in our society. These two disorders are often accompanied by other comorbidities, such as sleep disorders, significantly impacting the quality of life of individuals with ASD and epilepsy. To date, clinical approaches have primarily been descriptive in nature. Therefore, this study aimed to analyze the relationship between ASD, epilepsy, and sleep disorders, exploring neurobiological dysfunctions and cognitive alterations. A total of 22 scientific articles were selected using a systematic literature review following the criteria established using the PRISMA model. The selected articles were gathered from major databases: Medline, PubMed, PsycINFO, Google Scholar, and Web of Science. Inclusion criteria specified that study participants had an official diagnosis of ASD, the article precisely described the evaluation parameters used in the study participants, and individual characteristics of the sleep disorders of the study participants were specified. The results indicate, firstly, that the primary cause of sleep disorders in this population is directly linked to abnormal serotonin behaviors. Secondly, significant alterations in memory, attention, and hyperactivity were observed. In conclusion, sleep disorders negatively impact the quality of life and neurocognitive development of the pediatric population with ASD and epilepsy.
自闭症谱系障碍（ASD）和癫痫在我们的社会中是越来越普遍的共病。这两种疾病常伴有其他共病，如睡眠障碍，严重影响了患有ASD和癫痫的个体的生活质量。迄今为止，临床方法本质上主要是描述性的。因此，本研究旨在分析ASD、癫痫和睡眠障碍之间的关系，探索神经生物学功能障碍和认知改变。使用系统文献综述，按照PRISMA模型确立的标准，共筛选出22篇科学文章。所选文章来自主要数据库：Medline、PubMed、PsycINFO、谷歌学术和科学网。纳入标准规定，研究参与者有ASD的官方诊断，文章准确描述了研究参与者使用的评估参数，并且明确了研究参与者睡眠障碍的个体特征。结果表明，首先，该人群睡眠障碍的主要原因与血清素行为异常直接相关。其次，观察到记忆、注意力和多动方面有显著改变。总之，睡眠障碍对患有ASD和癫痫的儿童人群的生活质量和神经认知发展有负面影响。
