Radu Șerban Matache, Florentin Savu Cornel, Alina Constantin Ancuta
Department of Cardio-Thoracic Pathology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Institute of Pneumology "Marius Nasta", 050159 Bucharest, Romania.
Diagnostics (Basel). 2023 Nov 9;13(22):3411. doi: 10.3390/diagnostics13223411.
We report the case of a 59-year-old female patient, a former smoker, who was diagnosed with bilateral pulmonary nodules. Extensive medical investigations were conducted, including a surgical lung biopsy, which led to the diagnosis of pulmonary amyloidoma. The diagnostic process was guided by the presence of a persistent, polymorphic, and nonspecific clinical picture, strengthened by imaging findings characterized by mixed nodular lesions and the addition of interstitial involvement, along with partial deterioration of the pulmonary parenchyma architecture. Although it is recognized as a benign tumor, pulmonary amyloidoma requires special care in order to rule out systemic involvement, association with lymphomas, or systemic amyloidosis. This case highlights the comprehensive investigations required in the presence of multiple pulmonary nodules and the wide range of possible diagnoses. It underscores the pivotal role of surgical lung biopsy and histopathological examination. The case is instructive, addressing a rare pathology, on the border between specialties, while also emphasizing potential evolving challenges and providing further insights into the clinical course of this disease.
我们报告了一例59岁的女性患者，她既往有吸烟史，被诊断为双侧肺结节。进行了广泛的医学检查，包括手术肺活检，最终诊断为肺淀粉样瘤。诊断过程以持续、多形性和非特异性的临床表现为指导，并通过以混合结节性病变为特征的影像学表现以及间质受累和肺实质结构部分恶化的情况得到强化。尽管肺淀粉样瘤被认为是一种良性肿瘤，但为了排除全身受累、与淋巴瘤的关联或系统性淀粉样变性，仍需要特别关注。该病例突出了在存在多个肺结节时所需的全面检查以及广泛的可能诊断。它强调了手术肺活检和组织病理学检查的关键作用。该病例具有指导意义，涉及一种罕见的病理学，处于各专业的交叉领域，同时也强调了潜在的不断演变的挑战，并为该疾病的临床过程提供了进一步的见解。
