Browder I W, Sherwood E, Williams D, Jones E, McNamee R, DiLuzio N
Am J Surg. 1987 Jan;153(1):25-33. doi: 10.1016/0002-9610(87)90197-8.
In an effort to assess the impact of enhanced macrophage function in acute pancreatitis, mice were subjected to a choline-deficient diet supplemented by ethionine to induce necrotizing pancreatitis. Treatment with the macrophage stimulant glucan resulted in improved survival rates (58 percent versus 14 percent) and maintenance of pancreatic architecture. Glucan treatment also resulted in decreased plasma and peritoneal trypsin activity, as well as increased trypsin-binding activity in the blood and peritoneal cavity. Plasma interleukin-1, as well as macrophage production of interleukin-1, were increased in the glucan-treated mice, which indicated enhanced macrophage function. These composite findings suggest that by enhancing diverse aspects of reticuloendothelial function, clinical use of immunomodulators may have significant impact on the pathogenesis of acute pancreatitis.
为了评估增强巨噬细胞功能在急性胰腺炎中的影响，对小鼠采用缺乏胆碱并补充乙硫氨酸的饮食来诱发坏死性胰腺炎。用巨噬细胞刺激剂葡聚糖进行治疗可提高存活率（58%对14%）并维持胰腺结构。葡聚糖治疗还可降低血浆和腹腔中的胰蛋白酶活性，以及增加血液和腹腔中的胰蛋白酶结合活性。葡聚糖治疗的小鼠血浆白细胞介素-1以及巨噬细胞产生的白细胞介素-1均增加，这表明巨噬细胞功能增强。这些综合研究结果表明，通过增强网状内皮系统功能的多个方面，免疫调节剂的临床应用可能对急性胰腺炎的发病机制产生重大影响。
