Lo Buglio Aurelio, Scioscia Giulia, Bellanti Francesco, Tondo Pasquale, Soccio Piera, Natale Matteo Pio, Lacedonia Donato, Vendemiale Gianluigi
Department of Medical and Surgical Sciences, Institute of Internal Medicine, University of Foggia, Policlinico of Foggia, 71122 Foggia, Italy.
Department of Medical and Surgical Sciences, Institute of Respiratoy Diseases, University of Foggia, Policlinico of Foggia, 71122 Foggia, Italy.
Metabolites. 2023 Nov 2;13(11):1123. doi: 10.3390/metabo13111123.
The Controlling Nutritional Status (CONUT) score is a simple screening tool able to assess poor nutritional status as well as to predict clinical adverse outcomes in different clinical settings. No data are available in older patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the CONUT score as a predictor of frequent exacerbations. We retrospectively enrolled 222 patients aged 65 years or older, classified in two groups according to the number of exacerbations (or hospitalizations because AECOPD) during the previous year. The two groups were further divided according to low (<5) or high (≥5) CONUT scores. A total of 67.2% of frequent exacerbators had a high CONUT score. These patients exhibited a significantly higher CAT score, lower FEV1 percentage value, and higher prevalence of severe GOLD stages compared to those with low CONUT. Multivariate analysis showed that a CONUT score ≥ 5 was the best independent predictor (OR 20.740, < 0.001) of the occurrence of ≥2 exacerbations (or 1 hospitalization) during the previous year. The CONUT score seemed to have a high prognostic value for frequent exacerbations for COPD in older patients. The predictive role of different CONUT score cut-off values needs to be validated in larger COPD populations in future multi-center, prospective clinical studies.
控制营养状态（CONUT）评分是一种简单的筛查工具，能够评估营养状况不佳，并预测不同临床环境中的临床不良结局。在老年慢性阻塞性肺疾病（COPD）患者中尚无相关数据。本研究旨在调查CONUT评分作为频繁急性加重预测指标的情况。我们回顾性纳入了222例65岁及以上的患者，根据上一年急性加重（或因慢性阻塞性肺疾病急性加重住院）的次数分为两组。两组再根据CONUT评分低（<5）或高（≥5）进一步划分。共有67.2%的频繁急性加重者CONUT评分高。与CONUT评分低的患者相比，这些患者的慢性阻塞性肺疾病评估测试（CAT）评分显著更高，第1秒用力呼气容积（FEV1）百分比值更低，严重慢性阻塞性肺疾病全球倡议（GOLD）分级的患病率更高。多因素分析显示，CONUT评分≥5是上一年发生≥2次急性加重（或1次住院）的最佳独立预测指标（比值比20.740，P<0.001）。CONUT评分似乎对老年COPD患者的频繁急性加重具有较高的预后价值。不同CONUT评分临界值的预测作用需要在未来多中心、前瞻性临床研究中的更大COPD人群中进行验证。
