牙评分与唾液尿毒症毒素的关系。
Association between Dental Scores and Saliva Uremic Toxins.
机构信息
Service de Néphrologie-Transplantation-Dialyse-Aphérèses, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France.
INSERM, Bio-Ingénierie Tissulaire (BioTis), UMR 1026, Université de Bordeaux, 33076 Bordeaux, France.
出版信息
Toxins (Basel). 2023 Nov 20;15(11):666. doi: 10.3390/toxins15110666.
Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins in the saliva. A total of 88 patients were included in the study, with chronic kidney disease stage 2 to 5 (without kidney replacement). We analysed the total concentrations of eight uremic toxins (trimethylamine N-oxide -TMAO-, Indoxyl Sulfate, P-cresyl-sulfate, Indole 3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid -CMPF-, Kynurenine, Hippuric acid and Phenylacetylglutamine) and three precursors of uremic toxins (Tyrosine, Phenylalanine and Tryptophan) in the saliva using LC-MS/MS. We observed, for the first time, the association between various dental scores: DMFT, FST, CPITN, and OHIS, and saliva uremic toxins and precursors: TMAO, indoxyl sulfate, or hippuric acid. Further prospective interventional studies are required to confirm our results.
慢性肾脏病患者的口腔健康常受到影响。我们进行了一项关于慢性肾脏病患者口腔健康的前瞻性研究，特别关注口腔健康问题与唾液中尿毒症毒素积累之间的关系。共有 88 名患者入组研究，其中慢性肾脏病 2 至 5 期（无肾脏替代治疗）。我们使用 LC-MS/MS 分析了唾液中 8 种尿毒症毒素（氧化三甲胺-TMAO-、硫酸吲哚酚、对甲酚硫酸盐、吲哚 3-乙酸、3-羧基-4-甲基-5-丙基-2-呋喃丙酸-CMPF-、犬尿氨酸、马尿酸和苯乙酰谷氨酰胺）和 3 种尿毒症毒素前体（酪氨酸、苯丙氨酸和色氨酸）的总浓度。我们首次观察到各种口腔评分（DMFT、FST、CPITN 和 OHIS）与唾液尿毒症毒素和前体（TMAO、硫酸吲哚酚或马尿酸）之间存在关联。需要进一步的前瞻性干预研究来证实我们的结果。
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