Marques Ana, Carabineiro Sónia A C, Aureliano Manuel, Faleiro Leonor
Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
Algarve Biomedical Center-Research Institute, 8005-139 Faro, Portugal.
Toxics. 2023 Oct 26;11(11):879. doi: 10.3390/toxics11110879.
The worldwide increase in antibiotic resistance poses a significant challenge, and researchers are diligently seeking new drugs to combat infections and prevent bacterial pathogens from developing resistance. Gold (I and III) complexes are suitable for this purpose. In this study, we tested four gold (I and III) complexes, () chlorotrimethylphosphine gold(I); () chlorotriphenylphosphine gold(I); () dichloro(2-pyridinecarboxylate) gold (III); and () 1,3-bis(2,6-diisopropylphenyl)imidazole-2-ylidene gold(I) chloride, for their antibacterial, antibiofilm, antiviral, and anti-quorum sensing activities. Results reveal that significantly inhibits DSM 1077 and ATCC 6538, while , , and only inhibit ATCC 6538. The minimum inhibitory concentration (MIC) of for ATCC 6538 is 0.59 μg/mL (1.91 μM), and for methicillin-resistant strains MRSA 12 and MRSA 15, it is 1.16 μg/mL (3.75 μM). For DSM 1077 (Gram-negative), the MIC is 4.63 μg/mL (15 μM), and for multi-resistant I731940778-1, it is 9.25 μg/mL (30 μM). Complex also disrupts biofilm formation in and after 6 h or 24 h exposure. Moreover, and 2 inhibit the replication of two enterobacteria phages. Anti-quorum sensing potential still requires further clarification. These findings highlight the potential of gold complexes as effective agents to combat bacterial and viral infections.
全球抗生素耐药性的增加构成了重大挑战，研究人员正在努力寻找新的药物来对抗感染并防止细菌病原体产生耐药性。金（I和III）配合物适用于此目的。在本研究中，我们测试了四种金（I和III）配合物，（）三甲基膦氯金（I）；（）三苯基膦氯金（I）；（）二氯（2-吡啶羧酸酯）金（III）；以及（）1,3-双（2,6-二异丙基苯基）咪唑-2-亚基氯化金（I）的抗菌、抗生物膜、抗病毒和群体感应抑制活性。结果表明， 显著抑制 DSM 1077和 ATCC 6538，而 、 和 仅抑制 ATCC 6538。 对 ATCC 6538的最小抑菌浓度（MIC）为0.59 μg/mL（1.91 μM），对耐甲氧西林 菌株MRSA 12和MRSA 15，其MIC为1.16 μg/mL（3.75 μM）。对于 DSM 1077（革兰氏阴性菌），MIC为4.63 μg/mL（15 μM），对于多重耐药 I731940778-1，其MIC为9.25 μg/mL（30 μM）。配合物 在暴露6小时或24小时后也会破坏 和 中的生物膜形成。此外， 和2抑制两种肠道杆菌噬菌体的复制。群体感应抑制潜力仍需进一步阐明。这些发现突出了金配合物作为对抗细菌和病毒感染的有效药物的潜力。
