Zheng Yiquan, He Yaling, Kang Ning, Zhang Caiyun, Liao Wei, Yuchi Yinghao, Liu Xiaotian, Hou Jian, Mao Zhenxing, Huo Wenqian, Zhang Kai, Tian Hezhong, Lin Hualiang, Wang Chongjian
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Department of Occupational and Environmental Health, Ministry of Education, Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
Toxics. 2023 Oct 27;11(11):885. doi: 10.3390/toxics11110885.
Evidence on the effect of long-term exposure to fine particulate matter (PM) on erythrocytosis and thrombocytosis prevalence was limited. We aimed to investigate the association of PM and its constituents with the risks of erythrocytosis and thrombocytosis. The present study included a total of 33,585 participants from the Henan Rural Cohort at baseline between 2015 and 2017. A hybrid satellite-based model was employed to estimate the concentrations of PM mass and its constituents (including black carbon [BC], nitrate [NO], ammonium [NH], inorganic sulfate [SO], organic matter [OM], and soil particles [SOIL]). The logistic regression model was used to assess the associations of single exposure to PM and its constituents with the risks of erythrocytosis and thrombocytosis, and the quantile G-computation method was applied to evaluate their joint exposure risk. For the independent association, the odds ratios for erythrocytosis/thrombocytosis with 1 μg/m increase was 1.049/1.043 for PM mass, 1.596/1.610 for BC, 1.410/1.231 for NH, 1.205/1.139 for NO, 1.221/1.359 for OM, 1.300/1.143 for SO, and 1.197/1.313 for SOIL. Joint exposure to PM and its components was also positively associated with erythrocytosis and thrombocytosis. The estimated weight of NH was found to be the largest for erythrocytosis, while OM had the largest weight for thrombocytosis. PM mass and its constituents were positively linked to prevalent erythrocytosis and thrombocytosis, both in single-exposure and joint-exposure models. Additionally, NH/OM was identified as a potentially responsible component for the association between PM and erythrocytosis/thrombocytosis.
关于长期暴露于细颗粒物（PM）对红细胞增多症和血小板增多症患病率影响的证据有限。我们旨在研究PM及其成分与红细胞增多症和血小板增多症风险之间的关联。本研究共纳入了2015年至2017年基线时来自河南农村队列的33585名参与者。采用基于卫星的混合模型来估算PM质量及其成分（包括黑碳[BC]、硝酸盐[NO]、铵[NH]、无机硫酸盐[SO]、有机物[OM]和土壤颗粒[SOIL]）的浓度。使用逻辑回归模型评估单次暴露于PM及其成分与红细胞增多症和血小板增多症风险之间的关联，并应用分位数G计算方法评估它们的联合暴露风险。对于独立关联，PM质量每增加1μg/m³时红细胞增多症/血小板增多症的优势比分别为1.049/1.043；BC为1.596/1.610；NH为1.410/1.231；NO为1.205/1.139；OM为1.221/1.359；SO为1.300/1.143；SOIL为1.197/1.313。PM及其成分的联合暴露也与红细胞增多症和血小板增多症呈正相关。发现NH对红细胞增多症的估计权重最大，而OM对血小板增多症的权重最大。在单暴露和联合暴露模型中，PM质量及其成分均与普遍存在的红细胞增多症和血小板增多症呈正相关。此外，NH/OM被确定为PM与红细胞增多症/血小板增多症之间关联的潜在责任成分。
