Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.
Mol Neurobiol. 2024 Jun;61(6):3578-3595. doi: 10.1007/s12035-023-03747-4. Epub 2023 Nov 24.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to a complex family of RNA-binding proteins that are essential to control alternative splicing, mRNA trafficking, synaptic plasticity, stress granule formation, cell cycle regulation, and axonal transport. Over the past decade, hnRNPs have been associated with different brain disorders such as Alzheimer's disease, multiple sclerosis, and schizophrenia. Given their essential role in maintaining cell function and integrity, it is not surprising that dysregulated hnRNP levels lead to neurological implications. This review aims to explore the primary functions of hnRNPs in neurons, oligodendrocytes, microglia, and astrocytes, and their roles in brain disorders. We also discuss proteomics and other technologies and their potential for studying and evaluating hnRNPs in brain disorders, including the discovery of new therapeutic targets and possible pharmacological interventions.
异质核核糖核蛋白（hnRNPs）属于 RNA 结合蛋白家族的一个复杂家族，对控制选择性剪接、mRNA 运输、突触可塑性、应激颗粒形成、细胞周期调控和轴突运输至关重要。在过去的十年中，hnRNPs 与不同的脑部疾病有关，如阿尔茨海默病、多发性硬化症和精神分裂症。鉴于它们在维持细胞功能和完整性方面的重要作用，hnRNP 水平失调导致神经学影响并不奇怪。本综述旨在探讨 hnRNPs 在神经元、少突胶质细胞、小胶质细胞和星形胶质细胞中的主要功能及其在脑部疾病中的作用。我们还讨论了蛋白质组学和其他技术及其在研究和评估脑部疾病中的 hnRNPs 的潜力，包括发现新的治疗靶点和可能的药物干预。
