Bicks Lucy K, Eyring Katherine Wade, Geschwind Daniel H
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Department of Psychiatry and Biobehavioral Sciences, Semel Institue, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Cell Genom. 2023 Mar 8;3(3):100279. doi: 10.1016/j.xgen.2023.100279.
How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al. perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the importance of cell-type- and isoform-specific protein interactions in ASD.
与自闭症谱系障碍（ASD）相关的罕见蛋白质破坏风险变异如何相互作用或在功能上趋同尚不清楚。平塔库达等人在诱导的人类神经元中进行了蛋白质组学研究，识别出1000多种相互作用，其中90%此前未曾报道，这凸显了细胞类型和亚型特异性蛋白质相互作用在自闭症谱系障碍中的重要性。
