Iguchi T, Takasugi N
Anat Embryol (Berl). 1986;175(1):53-5. doi: 10.1007/BF00315455.
Polyovular follicles (PF) occur in the ovary of 30-day-old offspring of ICR/JCL mice given 4 daily subcutaneous injections of 20-2,000 micrograms diethylstilbestrol (DES)/day from days 15 to 18 of gestation. PF containing 2-9 oocytes per follicle in the prenatally DES-exposed mice are increased 33- to 112-fold as compared to controls. In 5- to 25-day-old offspring of mothers given injections of 2,000 micrograms DES/day, PF are observed 17-65 times more frequent than in controls.
多卵卵泡（PF）出现在妊娠第15至18天每天皮下注射4次、每次20 - 2000微克己烯雌酚（DES）的ICR/JCL小鼠30日龄后代的卵巢中。与对照组相比，产前暴露于DES的小鼠每个卵泡含2 - 9个卵母细胞的PF增加了33至112倍。在每天注射2000微克DES的母亲的5至25日龄后代中，观察到PF出现的频率比对照组高17至65倍。
