Lee Sungwoon, Bi Liyan, Chen Hao, Lin Dong, Mei Rongchao, Wu Yixuan, Chen Lingxin, Joo Sang-Woo, Choo Jaebum
Department of Chemistry, Chung-Ang University, Seoul 06974, South Korea.
School of Special Education and Rehabilitation, Binzhou Medical University, Yantai, 264003, China.
Chem Soc Rev. 2023 Dec 11;52(24):8500-8530. doi: 10.1039/d3cs00709j.
Advances in microfluidic device miniaturization and system integration contribute to the development of portable, handheld, and smartphone-compatible devices. These advancements in diagnostics have the potential to revolutionize the approach to detect and respond to future pandemics. Accordingly, herein, recent advances in point-of-care testing (POCT) of coronavirus disease 2019 (COVID-19) using various microdevices, including lateral flow assay strips, vertical flow assay strips, microfluidic channels, and paper-based microfluidic devices, are reviewed. However, visual determination of the diagnostic results using only microdevices leads to many false-negative results due to the limited detection sensitivities of these devices. Several POCT systems comprising microdevices integrated with portable optical readers have been developed to address this issue. Since the outbreak of COVID-19, effective POCT strategies for COVID-19 based on optical detection methods have been established. They can be categorized into fluorescence, surface-enhanced Raman scattering, surface plasmon resonance spectroscopy, and wearable sensing. We introduced next-generation pandemic sensing methods incorporating artificial intelligence that can be used to meet global health needs in the future. Additionally, we have discussed appropriate responses of various testing devices to emerging infectious diseases and prospective preventive measures for the post-pandemic era. We believe that this review will be helpful for preparing for future infectious disease outbreaks.
微流控设备小型化和系统集成方面的进展推动了便携式、手持式以及与智能手机兼容设备的发展。诊断领域的这些进步有可能彻底改变检测和应对未来大流行的方法。因此，本文综述了使用各种微型设备（包括侧向流动分析条、垂直流动分析条、微流控通道和纸基微流控设备）对2019冠状病毒病（COVID-19）进行即时检测（POCT）的最新进展。然而，仅使用微型设备进行诊断结果的视觉判定会由于这些设备有限的检测灵敏度而导致许多假阴性结果。为解决这一问题，已经开发了几种将微型设备与便携式光学阅读器集成的POCT系统。自COVID-19疫情爆发以来，基于光学检测方法的有效的COVID-19即时检测策略已经确立。它们可分为荧光、表面增强拉曼散射、表面等离子体共振光谱和可穿戴传感。我们介绍了结合人工智能的下一代大流行传感方法，这些方法可用于满足未来的全球健康需求。此外，我们还讨论了各种检测设备对新出现的传染病的适当应对措施以及大流行后时代的前瞻性预防措施。我们相信这篇综述将有助于为未来的传染病爆发做好准备。
