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基于表面增强拉曼散射检测的用于疾病诊断的微流控技术。

Microfluidics for disease diagnostics based on surface-enhanced raman scattering detection.

作者信息

Yu Xiangdong, Park Sohyun, Lee Sungwoon, Joo Sang-Woo, Choo Jaebum

机构信息

Department of Chemistry, Chung-Ang University, Seoul, 06974, South Korea.

Department of Chemistry, Soongsil University, Seoul, 06978, South Korea.

出版信息

Nano Converg. 2024 Apr 30;11(1):17. doi: 10.1186/s40580-024-00424-7.

DOI:10.1186/s40580-024-00424-7
PMID:38687445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11061072/
Abstract

This review reports diverse microfluidic systems utilizing surface-enhanced Raman scattering (SERS) detection for disease diagnosis. Integrating SERS detection technology, providing high-sensitivity detection, and microfluidic technology for manipulating small liquid samples in microdevices has expanded the analytical capabilities previously confined to larger settings. This study explores the principles and uses of various SERS-based microfluidic devices developed over the last two decades. Specifically, we investigate the operational principles of documented SERS-based microfluidic devices, including continuous-flow channels, microarray-embedded microfluidic channels, droplet microfluidic channels, digital droplet channels, and gradient microfluidic channels. We also examine their applications in biomedical diagnostics. In conclusion, we summarize the areas requiring further development to translate these SERS-based microfluidic technologies into practical applications in clinical diagnostics.

摘要

本综述报道了利用表面增强拉曼散射（SERS）检测技术进行疾病诊断的多种微流控系统。将具有高灵敏度检测能力的SERS检测技术与用于在微型设备中操控小液体样本的微流控技术相结合，扩展了以前仅限于较大规模环境的分析能力。本研究探讨了过去二十年来开发的各种基于SERS的微流控设备的原理和用途。具体而言，我们研究了已报道的基于SERS的微流控设备的操作原理，包括连续流通道、嵌入微阵列的微流控通道、液滴微流控通道、数字液滴通道和梯度微流控通道。我们还考察了它们在生物医学诊断中的应用。总之，我们总结了需要进一步发展的领域，以便将这些基于SERS的微流控技术转化为临床诊断中的实际应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/ef055d9ed3fe/40580_2024_424_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/c596e2b6dd82/40580_2024_424_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/e85c8e20ba74/40580_2024_424_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/c3a20711d61f/40580_2024_424_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/57d41ec98d9d/40580_2024_424_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/7215c4559367/40580_2024_424_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/b691479c8df3/40580_2024_424_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/409121e8d0c1/40580_2024_424_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/20c8ac2ef767/40580_2024_424_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/096933f8e96a/40580_2024_424_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/16eb1e6d917c/40580_2024_424_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/32a50d9a9d91/40580_2024_424_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/11e117ccfdff/40580_2024_424_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/ef055d9ed3fe/40580_2024_424_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/c596e2b6dd82/40580_2024_424_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/e85c8e20ba74/40580_2024_424_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/c3a20711d61f/40580_2024_424_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/57d41ec98d9d/40580_2024_424_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/7215c4559367/40580_2024_424_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/b691479c8df3/40580_2024_424_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/409121e8d0c1/40580_2024_424_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/20c8ac2ef767/40580_2024_424_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/096933f8e96a/40580_2024_424_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/16eb1e6d917c/40580_2024_424_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/32a50d9a9d91/40580_2024_424_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/11e117ccfdff/40580_2024_424_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8026/11061072/ef055d9ed3fe/40580_2024_424_Fig13_HTML.jpg

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