Department of Biological Sciences, Purdue Institute for Integrative Neuroscience, Purdue Autism Research Center, Purdue University, West Lafayette, IN 47907, USA.
Department of Computer Sciences, Iowa State University, Ames, IA 50011, USA.
Cell Rep. 2023 Dec 26;42(12):113482. doi: 10.1016/j.celrep.2023.113482. Epub 2023 Nov 22.
Visual perceptual experience induces persistent 4-8 Hz oscillations in the mouse primary visual cortex (V1), encoding visual familiarity. Recent studies suggest that higher-order visual areas (HVAs) are functionally specialized and segregated into information streams processing distinct visual features. However, whether visual memories are processed and stored within the distinct streams is not understood. We report here that V1 and lateromedial (LM), but not V1 and anterolateral, become more phase synchronized in 4-8 Hz after the entrainment of visual stimulus that maximally induces responses in LM. Directed information analysis reveals changes in the top-down functional connectivity between V1 and HVAs. Optogenetic inactivation of LM reduces post-stimulus oscillation peaks in V1 and impairs visual discrimination behavior. Our results demonstrate that 4-8 Hz familiarity-evoked oscillations are specific for the distinct visual features and are present in the corresponding HVAs, where they may be used for the inter-areal communication with V1 during memory-related behaviors.
视觉感知体验会在小鼠初级视觉皮层（V1）中诱导出持续的 4-8 Hz 振荡，从而对视觉熟悉度进行编码。最近的研究表明，高级视觉区域（HVAs）在功能上是专门化的，并分为处理不同视觉特征的信息流。然而，视觉记忆是否在这些不同的信息流中被处理和存储尚不清楚。我们在此报告，在 V1 和后外侧（LM）而不是 V1 和前外侧，在最大程度地诱导 LM 反应的视觉刺激诱发后，4-8 Hz 的相位同步性增强。定向信息分析揭示了 V1 和 HVAs 之间自上而下的功能连接的变化。LM 的光遗传学失活会降低 V1 中的刺激后振荡峰值，并损害视觉辨别行为。我们的结果表明，4-8 Hz 的熟悉度诱发的振荡是特定于不同的视觉特征的，并且存在于相应的 HVAs 中，在这些区域中，它们可能在与记忆相关的行为中与 V1 进行区域间通信。
