儿童接触全身麻醉与自闭症谱系障碍的关联。
Association Between Exposure of Children to General Anesthesia and Autism Spectrum Disorder.
机构信息
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, 200 First St SW, Rochester, MN, 55905, USA.
出版信息
J Autism Dev Disord. 2022 Oct;52(10):4301-4310. doi: 10.1007/s10803-021-05305-0. Epub 2021 Oct 7.
Abstract
This study tested the hypothesis that exposure of children prior to their third birthday to procedures requiring general anesthesia is associated with an increased incidence of autism spectrum disorder (ASD) in later life. This study employed a nested, 1:2 matched-case control study design using ASD cases identified in a population-based birth cohort of children born in Olmsted County, MN from 1976 to 2000. Matching variables included sex, date of birth, and mother's age in conditional logistic regression including 499 ASD cases and 998 controls. After adjusting for birth weight and health status, there was no significant association between exposure and ASD (OR 1.27 [95% CI 0.92-1.76]), indicating that general anesthesia is not associated with an increased risk of ASD.
摘要
本研究检验了这样一个假设，即儿童在三岁生日之前接受需要全身麻醉的手术会增加其日后患自闭症谱系障碍（ASD）的几率。这项研究采用了嵌套式、1:2 匹配病例对照研究设计，使用了明尼苏达州奥姆斯特德县的一个基于人群的出生队列中在 1976 年至 2000 年间出生的儿童中的 ASD 病例。匹配变量包括性别、出生日期和母亲的年龄，使用条件逻辑回归包括 499 例 ASD 病例和 998 例对照。在调整了出生体重和健康状况后，暴露与 ASD 之间没有显著关联（OR 1.27 [95% CI 0.92-1.76]），这表明全身麻醉与 ASD 风险增加无关。
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