Villanueva-García Dina, Ghezzi Marcelo, Mora-Medina Patricia, Hernández-Ávalos Ismael, Olmos-Hernández Adriana, Casas-Alvarado Alejandro, Lezama-García Karina, Domínguez-Oliva Adriana, Rodríguez-González Daniela, Marcet-Rius Miriam
Division of Neonatology, National Institute of Health, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.
Animal Welfare Area, Faculty of Veterinary Sciences (FCV), Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), University Campus, Tandil 7000, Argentina.
Animals (Basel). 2023 Nov 12;13(22):3491. doi: 10.3390/ani13223491.
Intrapartum asphyxia, fetal hypoxia, and their consequences (e.g., acidosis, hypercapnia, hypoglycemia, and hypothermia) are the main factors related to physio-metabolic imbalances that increase neonatal mortality in piglets, particularly in piglets with low birthweight and low vitality scores. This study aimed to evaluate the effect of three different doses of caffeine (10, 20, and 30 mg/kg) administered orally to 480 newborn piglets with low birthweight and low vitality scores. Blood gas parameters (pH, pO, pCO, and HCO), physio-metabolic profile (Ca, glucose, and lactate), and the thermal response assessed through infrared thermography in four thermal windows (ocular, auricular, snout, and hindlimb) and rectal temperature were evaluated during the first 24 h of life. Doses of 30 mg/kg resulted in significant differences at 24 h for all evaluated parameters, suggesting that caffeine administration improved the cardiorespiratory function and metabolic activity of piglets by reducing acidosis, restoring glycemia, and increasing surface and rectal temperature. In conclusion, caffeine at 30 mg/kg could be suggested as an appropriate dose to use in piglets with low birthweight and low vitality scores. Future research might need to study the presentation of adverse effects due to higher caffeine concentrations.
产时窒息、胎儿缺氧及其后果（如酸中毒、高碳酸血症、低血糖和体温过低）是与生理代谢失衡相关的主要因素，这些失衡会增加仔猪的新生儿死亡率，尤其是出生体重低和活力评分低的仔猪。本研究旨在评估对480头出生体重低和活力评分低的新生仔猪口服三种不同剂量咖啡因（10、20和30mg/kg）的效果。在出生后24小时内评估血气参数（pH、pO、pCO和HCO）、生理代谢指标（钙、葡萄糖和乳酸），并通过四个热窗（眼部、耳部、口鼻部和后肢）的红外热成像评估热反应以及直肠温度。30mg/kg剂量在24小时时所有评估参数均有显著差异，表明给予咖啡因可通过减轻酸中毒、恢复血糖水平以及提高体表温度和直肠温度来改善仔猪的心肺功能和代谢活动。总之，30mg/kg的咖啡因可被建议作为出生体重低和活力评分低的仔猪的合适使用剂量。未来的研究可能需要研究更高咖啡因浓度所导致的不良反应表现。
