Tutton P J, Barkla D H
Anticancer Res. 1986 Sep-Oct;6(5):1123-6.
Serotonin has previously been shown to stimulate cell proliferation in the jejunal crypt epithelium and in colonic tumours. The original classification of serotonin receptors into D and M groups was not conductive to the understanding of these observations. The more recent classification of serotonin receptors into 5HT1 and 5HT2 groups is considered in this report. On the balance of evidence it appears that similar receptors mediate the response to serotonin in the two tissues under consideration and that these receptors resemble those of the 5HT1 group. Such receptors are usually positively linked to adenylate cyclase.
血清素先前已被证明可刺激空肠隐窝上皮和结肠肿瘤中的细胞增殖。血清素受体最初分为D组和M组，这不利于对这些观察结果的理解。本报告考虑了血清素受体最近分为5HT1和5HT2组的分类。根据现有证据，似乎在所考虑的两种组织中，类似的受体介导对血清素的反应，并且这些受体类似于5HT1组的受体。这类受体通常与腺苷酸环化酶呈正相关。
