Tutton P J, Barkla D H
Anticancer Res. 1982 Jul-Aug;2(4):199-201.
A number of hormones, including some steroids, have previously been shown to influence the rate of cell division in the colonic crypt epithelium and in colonic tumours. In this report the effect of oophorectomy and of treatment with ovarian hormones on cell proliferation in these tissues is compared. Colonic tumours cell proliferation was retarded following oophorectomy and this retardation was reversed by the administration of oestradiol, but not by the administration of progesterone. Oophorectomy did not retard cell proliferation in the colonic crypts. The possible significance of these findings in relation to age-dependent variations in the sex ratio for human bowel cancer is discussed.
此前已证实，包括某些类固醇在内的多种激素会影响结肠隐窝上皮和结肠肿瘤中的细胞分裂速率。在本报告中，对卵巢切除术及卵巢激素治疗对这些组织中细胞增殖的影响进行了比较。卵巢切除术后，结肠肿瘤细胞增殖受到抑制，而给予雌二醇可逆转这种抑制作用，但给予孕酮则不能。卵巢切除术并未抑制结肠隐窝中的细胞增殖。本文讨论了这些发现与人类肠癌性别比例随年龄变化的可能相关性。
