血清素对大鼠结肠隐窝上皮及结肠腺癌有丝分裂率的影响。

The influence of serotonin on the mitotic rate in the colonic crypt epithelium and in colonic adenocarcinoma in rats.

Tutton P J, Barkla D H

Clin Exp Pharmacol Physiol. 1978 Jan-Feb;5(1):91-4. doi: 10.1111/j.1440-1681.1978.tb00657.x.

Abstract

The mitotic rate in the crypts of Lieberkühn of the descending colon and in dimethylhydrazine-induced adenocarcinomata of the descending colon of rat was measured using a stathmokinetic technique. 2. Intraperitoneal injection of a small dose (10 microgram/kg) of serotonin resulted in an increase in the tumour cell mitotic rate. 3. Blockade of serotonin receptors by 2-bromolysergic acid diethylamide and depletion of tissue serotonin levels following injection of DL-6-fluorotryptophan both result in a decrease in the tumour cell mitotic rate. 4. Treatment with serotonin, 2-bromolysergic acid diethylamide and DL-6-fluorotryptophan were all without effect on the colonic crypt cell mitotic rate.

摘要

采用有丝分裂阻断技术测定大鼠降结肠的利伯kühn隐窝以及二甲基肼诱导的大鼠降结肠腺癌中的有丝分裂率。2. 腹腔注射小剂量（10微克/千克）的血清素会导致肿瘤细胞有丝分裂率增加。3. 2-溴麦角酰二乙胺阻断血清素受体以及注射DL-6-氟色氨酸后组织血清素水平降低均会导致肿瘤细胞有丝分裂率下降。4. 血清素、2-溴麦角酰二乙胺和DL-6-氟色氨酸处理对结肠隐窝细胞有丝分裂率均无影响。