College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China.
Research Center of Cattle and Sheep Embryo Engineering Technique of Hebei Province, Baoding 071000, China.
Int J Mol Sci. 2023 Nov 7;24(22):16019. doi: 10.3390/ijms242216019.
Early embryonic development relies on the maternal RNAs and newly synthesized proteins during oogenesis. Zygotic transcription is an important event occurring at a specific time after fertilization. If no zygotic transcription occurs, the embryo will die because it is unable to meet the needs of the embryo and continue to grow. During the early stages of embryonic development, the correct transcription, translation, and expression of genes play a crucial role in blastocyst formation and differentiation of cell lineage species formation among mammalian species, and any variation may lead to developmental defects, arrest, or even death. Abnormal expression of some genes may lead to failure of the embryonic zygote genome before activation, such as BDNF and YBX1; Decreased expression of CENPF, ZSCAN4, TEAD4, GLIS1, and USF1 genes can lead to embryonic development failure. This article reviews the results of studies on the timing and mechanism of gene expression of these genes in bovine fertilized eggs/embryos.
早期胚胎发育依赖于卵母细胞发生过程中的母体 RNA 和新合成的蛋白质。合子转录是在受精后特定时间发生的重要事件。如果没有合子转录，胚胎将死亡，因为它无法满足胚胎的需求并继续生长。在胚胎发育的早期阶段，基因的正确转录、翻译和表达对于囊胚形成和哺乳动物种系细胞谱系的分化起着至关重要的作用，任何变异都可能导致发育缺陷、停滞甚至死亡。一些基因的异常表达可能导致胚胎合子基因组在激活前失效，如 BDNF 和 YBX1；CENPF、ZSCAN4、TEAD4、GLIS1 和 USF1 基因表达的降低可导致胚胎发育失败。本文综述了这些基因在牛受精卵/胚胎中表达的时间和机制的研究结果。
