Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.
Biomolecules. 2020 Apr 11;10(4):591. doi: 10.3390/biom10040591.
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell, tissue, or the whole organism. This review describes the involvement of YB proteins in RNA-dependent processes, such as mRNA packaging into mRNPs, mRNA translation, and mRNA stabilization. In addition, recent data on the structural peculiarities of YB proteins underlying their interactions with nucleic acids are discussed.
Y 盒结合蛋白（YB 蛋白）是 DNA/RNA 结合蛋白，属于冷休克域的大型蛋白家族。从功能上讲，这些蛋白质是最为多样化的，尽管文献几乎没有提供任何分子机制来控制它们在细胞、组织或整个生物体中的活性。本综述描述了 YB 蛋白在 RNA 依赖性过程中的参与，例如 mRNA 包装成 mRNPs、mRNA 翻译和 mRNA 稳定。此外，还讨论了最近关于 YB 蛋白与核酸相互作用的结构特性的数据。
