Laboratory of Separation and Spectroscopic Method Applications, Department of Chemistry, Institute of Biological Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, 20-708 Lublin, Poland.
Laboratory of Separation and Spectroscopic Method Applications, The John Paul II Catholic University of Lublin, 20-708 Lublin, Poland.
Int J Mol Sci. 2023 Nov 14;24(22):16304. doi: 10.3390/ijms242216304.
Tryptophan metabolism plays an essential role in human health. In mammals, about 95% of dietary tryptophan is metabolized through the kynurenine pathway, which is associated with the development of several pathologies, including neurodegeneration. Some of the kynurenine pathway metabolites are agonists of the aryl hydrocarbon receptor involved in metabolic functions, inflammation, and carcinogenesis. Thus, their origins, fates, and roles are of widespread interest. Except for being produced endogenously, these metabolites can originate from exogenous sources (e.g., food) and undergo absorption in the digestive tract. Recently, a special focus on exogenous sources of tryptophan metabolites was observed. This overview summarizes current knowledge about the occurrence of the kynurenine pathway metabolites (kynurenines) in food and the analytical method utilized for their determination in different food matrices. Special attention was paid to sample preparation and chromatographic analysis, which has proven to be a core technique for the detection and quantification of kynurenines. A discussion of the fate and role of dietary kynurenines has also been addressed. This review will, hopefully, guide further studies on the impact of dietary kynurenines on human health.
色氨酸代谢在人类健康中起着至关重要的作用。在哺乳动物中，约 95%的膳食色氨酸通过犬尿氨酸途径代谢，该途径与多种病理学的发展有关，包括神经退行性变。一些犬尿氨酸途径代谢物是芳烃受体的激动剂，参与代谢功能、炎症和癌变。因此，它们的起源、命运和作用引起了广泛的关注。除了内源性产生外，这些代谢物还可以来源于外源性来源（例如食物），并在消化道中被吸收。最近，人们特别关注色氨酸代谢物的外源性来源。这篇综述总结了目前关于食物中犬尿氨酸途径代谢物（犬尿氨酸）的存在以及用于不同食物基质中这些代谢物测定的分析方法的知识。特别关注了样品制备和色谱分析，这已被证明是检测和定量犬尿氨酸的核心技术。还讨论了饮食犬尿氨酸的命运和作用。希望这篇综述将指导进一步研究饮食犬尿氨酸对人类健康的影响。
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