Gilhar A, Krueger G G
Arch Dermatol. 1987 Jan;123(1):44-50.
A basic question in both mild and severe forms of alopecia areata (AA) relates to whether the disease is inherent to the affected tissue or secondary to circulating factors. This question has been addressed by grafting 2-mm grafts of scalp from affected areas of seven patients with AA or alopecia universalis (AU) onto congenitally athymic (nude) mice. Hair growth in these grafts has been compared with that of 2-mm grafts from hair-bearing skin remnants from two individuals undergoing elective plastic surgical procedures. Because cyclosporine seems to directly affect hair growth, a group of grafted mice was treated with this agent. By day 48, hair growth was present in many surviving grafts. Cyclosporine affected hair growth; this was most prominent by day 78 when the number of hairs per graft and the mean length of hair had increased significantly over untreated groups. Grafts from patients with AU had more hairs per graft and had greater hair length than did similar grafts from patients with AA. These experiments show that hair growth ability in situ is likely normal in AA and AU, and that the factors causative to this disease in situ are mediated humorally. Furthermore, cyclosporine seems to directly influence hair growth in this model system.
斑秃（AA）无论是轻度还是重度形式，一个基本问题都与该疾病是受影响组织固有的，还是继发于循环因子有关。通过将7例斑秃或全秃（AU）患者患病区域的2毫米头皮移植物移植到先天性无胸腺（裸）小鼠身上，这个问题得到了解决。这些移植物中的毛发生长情况已与两名接受择期整形手术患者有毛发皮肤残余部分的2毫米移植物的毛发生长情况进行了比较。由于环孢素似乎直接影响毛发生长，一组移植小鼠用该药物进行了治疗。到第48天时，许多存活的移植物中出现了毛发生长。环孢素影响了毛发生长；到第78天时最为明显，此时每个移植物的毛发数量和毛发平均长度比未治疗组显著增加。与AA患者的类似移植物相比，AU患者的移植物每个移植物的毛发更多，毛发长度更长。这些实验表明，AA和AU患者原位的毛发生长能力可能是正常的，并且该疾病原位的致病因素是通过体液介导的。此外，在这个模型系统中，环孢素似乎直接影响毛发生长。
