Radu Dusman Ramona-Daniela, Voicu Manuela Elena, Prodana Mariana, Demetrescu Ioana, Anuta Valentina, Draganescu Doina
Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.
Academy of Romanian Scientists, 3 Ilfov Street, 050044 Bucharest, Romania.
Materials (Basel). 2023 Nov 20;16(22):7237. doi: 10.3390/ma16227237.
The current study presents research about electrodeposition in relation to electrospinning PCL wires on a Zr substrate and loading the coating with vancomycin. The structural composition of the coatings was investigated via FT-IR analysis. The morphology evaluated using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy, for the composition (SEM-EDS), evidenced the presence of the polymer wires, with and without drug vancomycin loading. The wettability of the coatings was evaluated from the hydrophobic-hydrophilic point of view, and the characterization was completed with mechanical and electrochemical tests. All the electrochemical tests performed in simulated body fluid highlighted that PCL represents a barrier against corrosion processes. The quantitative method to evaluate the loading efficiency shows that almost 80% of the total loaded vancomycin is released within 144 h; after the initial burst at 24 h, a steady release of vancomycin is observed over 7 days. A kinetic model of the drug release was also constructed.
当前的研究展示了关于在锆基底上电纺聚己内酯（PCL）丝并负载万古霉素涂层的电沉积研究。通过傅里叶变换红外光谱（FT-IR）分析研究了涂层的结构组成。使用扫描电子显微镜结合能量色散X射线光谱（SEM-EDS）对形态进行评估，以确定其组成，结果表明存在负载和未负载万古霉素药物的聚合物丝。从疏水 - 亲水角度评估了涂层的润湿性，并通过机械和电化学测试完成了表征。在模拟体液中进行的所有电化学测试都突出表明，PCL是防止腐蚀过程的屏障。评估负载效率的定量方法表明，几乎80%的总负载万古霉素在144小时内释放；在24小时的初始突释后，观察到万古霉素在7天内稳定释放。还构建了药物释放的动力学模型。
