Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education), Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai 264005, China.
School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Molecules. 2023 Nov 10;28(22):7517. doi: 10.3390/molecules28227517.
Paclitaxel, a natural secondary metabolite isolated and purified from the bark of the tree, is considered one of the most successful natural anticancer drugs due to its low toxicity, high potency and broad-spectrum anticancer activity. trees are scarce and slow-growing, and with extremely low paclitaxel content, the contradiction between supply and demand in the market is becoming more and more intense. Therefore, researchers have tried to obtain paclitaxel by various methods such as chemical synthesis, artificial culture, microbial fermentation and tissue cell culture to meet the clinical demand for this drug. This paper provides a comprehensive overview of paclitaxel extraction, combination therapy, total synthesis, semi-synthesis and biosynthesis in recent years and provides an outlook, aiming to provide a theoretical basis and reference for further research on the production and application of paclitaxel in the future.
紫杉醇是从树皮中分离和纯化的天然次生代谢物，因其低毒性、高效性和广谱抗癌活性而被认为是最成功的天然抗癌药物之一。但由于 树资源稀缺，生长缓慢，紫杉醇含量极低，市场供需矛盾日益加剧。因此，研究人员试图通过化学合成、人工培养、微生物发酵和组织细胞培养等各种方法获得紫杉醇，以满足临床对该药物的需求。本文综述了近年来紫杉醇的提取、联合治疗、全合成、半合成和生物合成的研究进展，并对其进行了展望，旨在为紫杉醇未来的生产和应用研究提供理论依据和参考。
