School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.
State Key Laboratory of Qinba Biological Resources and Ecological Environment, Hanzhong 723000, China.
Molecules. 2023 Nov 20;28(22):7669. doi: 10.3390/molecules28227669.
Chromium picolinate (CP) is an organic compound that has long been used to treat diabetes. Our previous studies found CP could relieve diabetic nephropathy. Thus, we speculate that it might have a positive effect on diabetic testicular injury. In this study, a diabetic rat model was established, and then the rats were treated with CP for 8 weeks. We found that the levels of blood glucose, food, and water intake were reduced, and body weight was enhanced in diabetic rats after CP supplementation. Meanwhile, in CP treatment groups, the levels of male hormone and sperm parameters were improved, the pathological structure of the testicular tissue was repaired, and testicular fibrosis was inhibited. In addition, CP reduced the levels of serum inflammatory cytokines, and decreased oxidative stress and apoptosis in the testicular tissue. In conclusion, CP could ameliorate testicular damage in diabetic rats, as well as being a potential testicle-protective nutrient in the future to prevent the testicular damage caused by diabetes.
吡啶甲酸铬（CP）是一种有机化合物，长期以来一直被用于治疗糖尿病。我们之前的研究发现 CP 可以缓解糖尿病肾病。因此，我们推测它可能对糖尿病睾丸损伤有积极影响。在这项研究中，建立了糖尿病大鼠模型，然后用 CP 治疗 8 周。我们发现，糖尿病大鼠补充 CP 后，血糖、食物和水的摄入量降低，体重增加。同时，在 CP 治疗组中，雄性激素和精子参数水平得到改善，睾丸组织的病理结构得到修复，睾丸纤维化受到抑制。此外，CP 降低了血清炎症细胞因子的水平，减少了睾丸组织中的氧化应激和细胞凋亡。总之，CP 可以改善糖尿病大鼠的睾丸损伤，并且可能成为未来预防糖尿病引起的睾丸损伤的潜在睾丸保护营养物质。
