Li Z, Xue C, Li S, Jing M, Liu S, Sun J, Ren T, Zhou J
Department of Imaging, Shaanxi Provincial People's Hospital, Xi'an, China.
Department of Radiology, Lanzhou University Second Hospital, Cuiyingmen No. 82, Chengguan District, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China; Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou, China.
Clin Radiol. 2024 Feb;79(2):e197-e203. doi: 10.1016/j.crad.2023.10.029. Epub 2023 Nov 11.
To explore the value of preoperative computed tomography (CT) histogram features in predicting the expression status of Ki-67 in patients with solid pseudopapillary pancreatic tumours (SPTP).
This retrospective study analysed venous phase CT images of 39 patients with SPTP confirmed at surgery and histopathology and measured using the Ki-67 proliferation index from November 2015 to February 2022. According to the Ki-67 proliferation index, they were divided into high expression (Ki-67 ≥ 4%) and low expression (Ki-67 < 4%) groups. The histogram features of quantitative parameters were extracted using MaZda software, and the quantitative parameters of CT histograms were compared between groups. The receiver operating characteristic (ROC) curves of the patients were plotted according to the parameters, with statistically significant differences. The area under the curve (AUC), sensitivity, and specificity were calculated, and the effectiveness of the histogram parameters in predicting Ki-67 expression was analysed and evaluated.
In total, 27 SPTP patients were enrolled, including 11 with high expression of Ki-67 and 16 with low expression. Comparative analysis of the Ki-67 high- and low-expression groups revealed a statistically significant in necrosis and variance (p<0.05). ROC curve analysis showed that the AUC of necrosis and variance predicting Ki-67 expression status were 0.753 and 0.841, the sensitivities were 81.8% and 81.3%, and the specificities were 68.7% and 81.8%, respectively.
Preoperative CT histogram features help predict Ki-67 expression status in patients with SPTP.
探讨术前计算机断层扫描（CT）直方图特征在预测实性假乳头状胰腺肿瘤（SPTP）患者Ki-67表达状态中的价值。
本回顾性研究分析了2015年11月至2022年2月期间39例经手术及组织病理学确诊为SPTP患者的静脉期CT图像，并采用Ki-67增殖指数进行测量。根据Ki-67增殖指数，将患者分为高表达（Ki-67≥4%）组和低表达（Ki-67<4%）组。使用MaZda软件提取定量参数的直方图特征，并比较两组间CT直方图的定量参数。根据具有统计学显著差异的参数绘制患者的受试者操作特征（ROC）曲线。计算曲线下面积（AUC）、灵敏度和特异度，并分析和评估直方图参数在预测Ki-67表达中的有效性。
共纳入27例SPTP患者，其中Ki-67高表达11例，低表达16例。Ki-67高表达组与低表达组的比较分析显示，坏死和方差差异有统计学意义（p<0.05）。ROC曲线分析显示，坏死和方差预测Ki-67表达状态的AUC分别为0.753和0.841，灵敏度分别为81.8%和81.3%，特异度分别为68.7%和81.8%。
术前CT直方图特征有助于预测SPTP患者的Ki-67表达状态。
