Das S K, Nair R C
Br J Haematol. 1980 Jan;44(1):87-92. doi: 10.1111/j.1365-2141.1980.tb01186.x.
Sickled erythrocytes showed reduced glutathione peroxidase and catalase activities in comparison to normal erythrocytes. In addition, increased levels of superoxide dismutase and 'peroxidation potential' as well as fluorescent lipid pigments and malonaldehyde suggestive of membrane lipid peroxidation were found in sickled erythrocytes. Finally, sickled erythrocytes showed membrane 'bound' Heinz bodies as well as reduced membrane lipids and unsaturated fatty acids. From these observations, it is suggested that membrane lipid peroxidation occurs in sickled cells.
与正常红细胞相比，镰状红细胞的谷胱甘肽过氧化物酶和过氧化氢酶活性降低。此外，在镰状红细胞中发现超氧化物歧化酶水平升高、“过氧化电位”升高，以及提示膜脂质过氧化的荧光脂质色素和丙二醛。最后，镰状红细胞显示出膜“结合”的亨氏小体以及膜脂质和不饱和脂肪酸减少。基于这些观察结果，提示镰状细胞中发生了膜脂质过氧化。
