溶酶体中的二硫键还原。半胱氨酸的作用。
Disulphide reduction in lysosomes. The role of cysteine.
作者信息
Lloyd J B
出版信息
Biochem J. 1986 Jul 1;237(1):271-2. doi: 10.1042/bj2370271.
Abstract
Published evidence indicates that cystine-containing proteins have their disulphide bonds reduced during proteolysis in lysosomes. However, the intralysosomal accumulation of cystine in the cells of patients with cystinosis has been seen as evidence that protein cystine residues are not reduced. The data are reconcilable and fully in harmony if it is postulated that cysteine from the cytoplasm is the physiological reducing agent.
摘要
已发表的证据表明，含胱氨酸的蛋白质在溶酶体中的蛋白水解过程中其二硫键会被还原。然而，胱氨酸病患者细胞中溶酶体内胱氨酸的积累被视为蛋白质胱氨酸残基未被还原的证据。如果假定来自细胞质的半胱氨酸是生理还原剂，那么这些数据是可以调和且完全一致的。
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本文引用的文献
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Modulation of the intracellular cystine content of cystinotic fibroblasts by extracellular albumin.细胞外白蛋白对胱氨酸病成纤维细胞细胞内胱氨酸含量的调节作用。
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Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine.胱氨酸在胱氨酸病成纤维细胞中以游离和蛋白质结合形式蓄积，但半胱氨酸不蓄积。
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