Onerup Aron, Mirzaei S Sedigheh, Bhatia Shalini, Ware Megan E, Joffe Lenat, Turcotte Lucie M, Goodenough Chelsea G, Sapkota Yadav, Dixon Stephanie B, Wogksch Matthew D, Ehrhardt Matthew J, Armstrong Gregory T, Hudson Melissa M, Ness Kirsten K
Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Cancer Rep (Hoboken). 2024 Jan;7(1):e1944. doi: 10.1002/cnr2.1944. Epub 2023 Nov 27.
Lifestyle is associated with meningioma risk in the general population.
We assessed longitudinal associations between lifestyle-associated factors and subsequent meningiomas in childhood cancer survivors.
Childhood cancer survivors age ≥18 years in the St. Jude Lifetime Cohort Study were evaluated for body composition, self-reported physical activity, cardiopulmonary fitness, muscle strength, smoking, and alcohol consumption at baseline. Time to first meningioma analyses were performed, adjusted for sex, age at diagnosis and baseline assessment, treatment decade, and childhood cancer treatment exposures. The study included 4,072 survivors (47% female; [mean (SD)] 9 (6) years at diagnosis; 30 (8.5) years at the start of follow-up, with 7.0 (3.3) years of follow-up). 30% of the participants were survivors of acute lymphoblastic leukemia and 29% of the participants had received cranial radiation. During follow-up, 90 participants developed ≥1 meningioma, of whom 73% were survivors of acute lymphoblastic leukemia, with cranial radiation being the strongest risk factor (relative risk [RR] 29.7, 95% confidence interval [CI] 10.6-83.2). Muscle strength assessed by knee extension was associated with a lower risk of developing a meningioma in the adjusted analyses (RR 0.5, 95% CI 0.2-1.0, p = 0.04 for quartiles 3-4 vs. 1). No other lifestyle-associated variable was associated with subsequent meningioma.
Independent of cranial radiation, muscle strength was associated with a lower risk of developing a subsequent meningioma in childhood cancer survivors.
在普通人群中，生活方式与脑膜瘤风险相关。
我们评估了儿童癌症幸存者中生活方式相关因素与后续脑膜瘤之间的纵向关联。
在圣裘德终身队列研究中，对年龄≥18岁的儿童癌症幸存者在基线时进行身体成分、自我报告的身体活动、心肺功能、肌肉力量、吸烟和饮酒情况的评估。对首次发生脑膜瘤的时间进行分析，并根据性别、诊断时年龄和基线评估、治疗年代以及儿童癌症治疗暴露情况进行调整。该研究纳入了4072名幸存者（47%为女性；诊断时平均（标准差）年龄为9（6）岁；随访开始时为30（8.5）岁，随访时间为7.0（3.3）年）。30%的参与者是急性淋巴细胞白血病幸存者，29%的参与者接受过颅脑放疗。在随访期间，90名参与者发生了≥1例脑膜瘤，其中73%是急性淋巴细胞白血病幸存者，颅脑放疗是最强的危险因素（相对风险[RR] 29.7，95%置信区间[CI] 10.6 - 83.2）。在调整分析中，通过膝关节伸展评估的肌肉力量与发生脑膜瘤的风险较低相关（四分位数3 - 4与1相比，RR 0.5，95% CI 0.2 - 1.0，p = 0.04）。没有其他生活方式相关变量与后续脑膜瘤相关。
独立于颅脑放疗，肌肉力量与儿童癌症幸存者发生后续脑膜瘤的风险较低相关。
