Abrosimov A Yu, Bondarenko E V, Pastuhova D A, Beloshitsky M E
Endocrinology Research Center, Moscow, Russia.
Moscow Regional Research and Clinical Institute, Moscow, Russia.
Arkh Patol. 2023;85(6):47-51. doi: 10.17116/patol20238506147.
Sclerosing mucoepidermoid carcinoma with stromal eosinophilia of thyroid gland is represented less than 100 cases in the world literature. We present a rare case of sclerosing mucoepidermoid carcinona with stromal eosinophilia in a 69-year-old woman who has been observed for multinodular goiter for more than 3 years. Cytological examination revealed a picture most of all corresponding to a malignant neoplasm (Bethesda V). The patient underwent a thyroidectomy. Pathomorphological examination revealed a neoplasm of mixed structure with foci of cribriform structures and squamous metaplasia with areas of keratinization. According to the IHC study, the expression of TTF-1, p63, cytokeratins 5/6 were positive, while there were no expression of thyroglobulin with its positive reaction in the thyroid tissue. Additional histochemical staining with Alcian blue revealed a positive reaction with a homogeneous acellular substance of the tumor. A comprehensive morphological study with the use of additional stains made it possible to accurately establish the diagnosis, which will determine the further tactics of managing the patient.
甲状腺硬化性黏液表皮样癌伴间质嗜酸性粒细胞增多在世界文献中报道不足100例。我们报告一例罕见的69岁女性甲状腺硬化性黏液表皮样癌伴间质嗜酸性粒细胞增多病例，该患者因多结节性甲状腺肿已接受观察3年多。细胞学检查显示的图像最符合恶性肿瘤（贝塞斯达Ⅴ类）。患者接受了甲状腺切除术。病理形态学检查显示肿瘤为混合结构，有筛状结构灶和鳞状化生伴角化区域。根据免疫组化研究，TTF-1、p63、细胞角蛋白5/6表达阳性，而甲状腺球蛋白在甲状腺组织中无表达，其反应为阳性。用阿尔辛蓝进行的额外组织化学染色显示肿瘤的均质无细胞物质呈阳性反应。使用额外染色剂进行的综合形态学研究使得准确诊断成为可能，这将决定患者的进一步治疗策略。
