Ren Wenzhu, Yan Yifei, Huang Yinhua
College of Materials, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China.
J Org Chem. 2023 Dec 15;88(24):16797-16802. doi: 10.1021/acs.joc.3c01297. Epub 2023 Nov 27.
Herein, a stereoselective copper-catalyzed decarboxylative silylation of readily available vinylethylene carbonates (VECs) with PhMeSi-Bpin is reported, affording a wide range of tri- and tetrasubstituted allylsilanes in moderate to high yields with -selectivity. This protocol was characterized by high stereoselectivity, broad substrate scope, operational simplicity, and mild reaction conditions, which were amenable to diverse derivatizations and gram-scale synthesis.
本文报道了一种立体选择性的铜催化的、用二(频哪醇合)甲基苯基硅烷对易于获得的碳酸乙烯基亚乙酯（VECs）进行脱羧硅基化反应，以中等至高产率和高立体选择性得到一系列三取代和四取代的烯丙基硅烷。该方法具有高立体选择性、底物范围广、操作简便以及反应条件温和的特点，适用于多种衍生化反应和克级规模的合成。
