Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, PR China.
J Obstet Gynaecol. 2023 Dec;43(2):2285025. doi: 10.1080/01443615.2023.2285025. Epub 2023 Nov 27.
This study was designed to investigate the association between nutrients and female infertility.
A cross-sectional study on 18-45 years of age reproductive-age women was conducted using the data from the National Health and Nutrition Examination Surveys (NHANES) for the periods 2013-2014 and 2015-2016. Multivariate logistic regression analysis was performed to evaluate the association between nutrients and female infertility. Subgroup analysis was applied to the body mass index (BMI). Results were summarised using an odds ratio (OR) with a 95% confidence interval (CI).
Of the total 1713 women, 204 women (11.91%) were infertile. The result demonstrated that higher intake of carbohydrate (OR: 0.46, 95% CI: 0.24-0.86, = 0.018), vitamin A (OR: 0.44, 95% CI: 0.24-0.80, = 0.009), vitamin C (OR: 0.48, 95% CI: 0.26-0.88, = 0.020), magnesium (OR: 0.36, 95% CI: 0.17-0.76, = 0.009), iron (OR: 0.43, 95% CI: 0.23-0.82, = 0.012), lycopene (OR: 0.55, 95% CI: 0.33-0.91, = 0.022), and total folate (OR: 0.38, 95% CI: 0.20-0.70, = 0.003) were associated with a lower risk of female infertility. The subgroup analysis also reported that intakes of vitamin A, vitamin C, and lycopene were related to a lower risk of female infertility among women with a BMI being 18.5-24.9 kg/m. Among women with BMI > 24.9 kg/m, high intakes of magnesium, iron and total folate were associated with a decreased risk of female infertility.
The intake of several nutrients is associated with a decreased risk of female infertility. These findings provide insight into potentially modifiable lifestyle factors associated with female infertility.
本研究旨在探讨营养素与女性不孕之间的关系。
使用 2013-2014 年和 2015-2016 年国家健康和营养检查调查（NHANES）的数据，对 18-45 岁育龄妇女进行了横断面研究。采用多变量 logistic 回归分析评估营养素与女性不孕之间的关系。对体重指数（BMI）进行了亚组分析。结果用比值比（OR）及其 95%置信区间（CI）表示。
在总共 1713 名女性中，204 名（11.91%）患有不孕。结果表明，较高的碳水化合物摄入（OR：0.46，95%CI：0.24-0.86， = 0.018）、维生素 A（OR：0.44，95%CI：0.24-0.80， = 0.009）、维生素 C（OR：0.48，95%CI：0.26-0.88， = 0.020）、镁（OR：0.36，95%CI：0.17-0.76， = 0.009）、铁（OR：0.43，95%CI：0.23-0.82， = 0.012）、番茄红素（OR：0.55，95%CI：0.33-0.91， = 0.022）和总叶酸（OR：0.38，95%CI：0.20-0.70， = 0.003）与女性不孕的风险降低相关。亚组分析还报告称，维生素 A、维生素 C 和番茄红素的摄入量与 BMI 在 18.5-24.9kg/m 之间的女性不孕风险降低有关。在 BMI>24.9kg/m 的女性中，高镁、铁和总叶酸的摄入量与女性不孕风险降低有关。
几种营养素的摄入与女性不孕风险降低有关。这些发现为潜在的可改变的与女性不孕相关的生活方式因素提供了新的见解。
