Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
Department of Psychiatry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Sleep. 2024 Jan 11;47(1). doi: 10.1093/sleep/zsad302.
Given the established racial disparities in both sleep health and dementia risk for African American populations, we assess cross-sectional and longitudinal associations of self-report sleep duration (SRSD) and daytime sleepiness with plasma amyloid beta (Aβ) and cognition in an African American (AA) cohort.
In a cognitively unimpaired sample drawn from the African Americans Fighting Alzheimer's in Midlife (AA-FAiM) study, data on SRSD, Epworth Sleepiness Scale, demographics, and cognitive performance were analyzed. Aβ40, Aβ42, and the Aβ42/40 ratio were quantified from plasma samples. Cross-sectional analyses explored associations between baseline predictors and outcome measures. Linear mixed-effect regression models estimated associations of SRSD and daytime sleepiness with plasma Aβ and cognitive performance levels and change over time.
One hundred and forty-seven participants comprised the cross-sectional sample. Baseline age was 63.2 ± 8.51 years. 69.6% self-identified as female. SRSD was 6.4 ± 1.1 hours and 22.4% reported excessive daytime sleepiness. The longitudinal dataset included 57 participants. In fully adjusted models, neither SRSD nor daytime sleepiness is associated with cross-sectional or longitudinal Aβ. Associations with level and trajectory of cognitive test performance varied by measure of sleep health.
SRSD was below National Sleep Foundation recommendations and daytime sleepiness was prevalent in this cohort. In the absence of observed associations with plasma Aβ, poorer self-reported sleep health broadly predicted poorer cognitive function but not accelerated decline. Future research is necessary to understand and address modifiable sleep mechanisms as they relate to cognitive aging in AA at disproportionate risk for dementia.
Not applicable.
鉴于非裔美国人的睡眠健康和痴呆风险存在既定的种族差异，我们评估了自我报告的睡眠时间（SRSD）和白天嗜睡与血浆淀粉样蛋白β（Aβ）和认知在非裔美国人（AA）队列中的横断面和纵向关联。
在从中年非裔美国人抗阿尔茨海默病（AA-FAiM）研究中抽取的认知未受损样本中，分析了 SRSD、嗜睡量表、人口统计学和认知表现的数据。从血浆样本中定量测定 Aβ40、Aβ42 和 Aβ42/40 比值。横断面分析探讨了基线预测因素与结局指标之间的关系。线性混合效应回归模型估计了 SRSD 和白天嗜睡与血浆 Aβ 和认知表现水平以及随时间变化的关系。
横断面样本由 147 名参与者组成。基线年龄为 63.2±8.51 岁。69.6%的人自我认同为女性。SRSD 为 6.4±1.1 小时，22.4%的人报告白天嗜睡过多。纵向数据集包括 57 名参与者。在完全调整的模型中，SRSD 和白天嗜睡均与横断面或纵向 Aβ 无关。与认知测试表现水平和轨迹的关联因睡眠健康测量而异。
SRSD 低于国家睡眠基金会的建议，且该队列中白天嗜睡较为普遍。在未观察到与血浆 Aβ 相关的情况下，较差的自我报告睡眠健康广泛预示着认知功能较差，但不能预示认知功能下降加速。需要进一步研究以了解和解决与痴呆风险不成比例的 AA 认知老化相关的可调节睡眠机制。
不适用。
Zotero 插件