Windon Charles, Iaccarino Leonardo, Mundada Nidhi, Allen Isabel, Boxer Adam L, Byrd Desiree, Rivera-Mindt Monica, Rabinovici Gil D
Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California San Francisco California USA.
Department of Epidemiology and Biostatistics University of California San Francisco California USA.
Alzheimers Dement (Amst). 2022 May 1;14(1):e12315. doi: 10.1002/dad2.12315. eCollection 2022.
Ethnoracial differences in cerebrospinal fluid (CSF; amyloid beta 42 [Aβ42], total tau [t-tau], phosphorylated tau 181 [p-tau181], and plasma (p-tau181, neurofilament light [NfL]) biomarkers of Alzheimer's disease (AD) are incompletely understood.
We performed cross-sectional analyses with and without adjustment for covariates comparing baseline CSF (Aβ42, t-tau, p-tau181) and plasma (p-tau181, NfL) values in 47 African Americans (AAs) matched to 141 non-Hispanic Whites (NHWs) and 43 Latinos (LAs) matched to 129 NHWs from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
Unadjusted comparisons revealed no significant differences in plasma or CSF biomarkers between AAs and NHWs. A trend toward a lower CSF t-tau and p-tau181 in LAs compared to NHWs was observed, without significant differences in plasma biomarkers. After adjusting for covariates, there were no significant differences in CSF or plasma biomarkers between AAs and NHWs or between LAs and NHWs.
Plasma and CSF AD biomarkers may perform similarly across diverse populations but future studies in large, diverse cohorts are needed.
阿尔茨海默病（AD）的脑脊液（CSF；淀粉样β蛋白42 [Aβ42]、总tau蛋白[t-tau]、磷酸化tau蛋白181 [p-tau181]）和血浆（p-tau181、神经丝轻链蛋白[NfL]）生物标志物在不同种族间的差异尚未完全明确。
我们对来自阿尔茨海默病神经影像倡议（ADNI）的47名非裔美国人（AA）与141名非西班牙裔白人（NHW）以及43名拉丁裔（LA）与129名NHW进行了横断面分析，比较了有无协变量调整时的基线CSF（Aβ42、t-tau、p-tau181）和血浆（p-tau181、NfL）值。
未经调整的比较显示，AA与NHW之间的血浆或CSF生物标志物无显著差异。观察到LA的CSF t-tau和p-tau181相较于NHW有降低趋势，血浆生物标志物无显著差异。在调整协变量后，AA与NHW之间或LA与NHW之间的CSF或血浆生物标志物均无显著差异。
血浆和CSF AD生物标志物在不同人群中的表现可能相似，但未来需要在大型、多样化队列中开展研究。
