University of Newcastle, New Lambton, New South Wales, Australia.
University of Newcastle, New Lambton, New South Wales, Australia.
J Am Med Dir Assoc. 2024 Dec;25(12):105299. doi: 10.1016/j.jamda.2024.105299. Epub 2024 Oct 10.
It has been proposed that abnormal sleep duration and excessive daytime sleepiness might be risk factors for dementia. This study assessed the interaction between sleep duration and excessive daytime sleepiness, and the effect of sleep duration in the presence or absence of excessive daytime sleepiness on dementia risk in community-dwelling older adults.
A longitudinal study.
Data from 2187 community-dwelling participants with mean age 70 years from the Hunter Community Study were included in this study.
Participants were classified as participants with long sleep duration (slept >8 hours per night), recommended sleep duration (7-8 hours) as per the National Sleep Foundation, or short sleep duration (slept <7 hours per night). The Berlin Questionnaire was used to identify excessive daytime sleepiness. Dementia was defined as per International Classification of Diseases, 10 Revision codes. To calculate all-cause dementia risk, the Fine-Gray sub-distribution hazard model was computed with death as a competing risk.
Over a mean follow-up of 6 years, 64 participants developed dementia and 154 deaths were identified. The average onset of dementia was 5.4 years. Long sleep duration was associated with increased dementia risk only in the presence of excessive daytime sleepiness (adjusted hazard ratio, 2.86; 95% confidence interval 1.03-7.91). A statistically significant interaction was found between excessive daytime sleepiness and sleep duration for all-cause dementia.
Long sleep duration with excessive daytime sleepiness was associated with increased risk of all-cause dementia. This suggests the importance of promoting awareness of healthy sleep and the possible role of nurturing good quantity and quality sleep in reducing the risk of dementia.
有研究提出，睡眠时间异常和日间过度嗜睡可能是痴呆的危险因素。本研究评估了睡眠时间与日间过度嗜睡之间的相互作用，以及在存在或不存在日间过度嗜睡的情况下，睡眠时间对社区居住的老年人痴呆风险的影响。
一项纵向研究。
本研究纳入了来自亨特社区研究的 2187 名平均年龄为 70 岁的社区居住参与者的数据。
参与者被分为长睡眠组（每晚睡眠时间>8 小时）、推荐睡眠时间组（按照国家睡眠基金会的建议为 7-8 小时）或短睡眠组（每晚睡眠时间<7 小时）。使用柏林问卷来确定日间过度嗜睡。痴呆的定义是根据国际疾病分类，第 10 次修订版的代码。为了计算全因痴呆风险，使用 Fine-Gray 亚分布风险模型，将死亡作为竞争风险进行计算。
在平均 6 年的随访中，64 名参与者患上了痴呆症，154 人死亡。痴呆症的平均发病时间为 5.4 年。只有在存在日间过度嗜睡的情况下，长睡眠时间才与痴呆风险增加相关（调整后的危险比，2.86；95%置信区间，1.03-7.91）。在全因痴呆方面，日间过度嗜睡和睡眠时间之间存在统计学显著的交互作用。
伴有日间过度嗜睡的长睡眠时间与全因痴呆风险增加相关。这表明，促进对健康睡眠的认识以及培养良好的睡眠质量和数量以降低痴呆风险的重要性。
