探讨 SARS-CoV-2 大流行引起的压力和焦虑对医护人员体液免疫的影响。
Examining the Effect of SARS-CoV-2 Pandemic-Induced Stress and Anxiety on Humoral Immunity in Health Care Workers.
机构信息
From the Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida (V.S.S., E.C.W., J.C., M.E.H.); Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida (S. Pallikkuth, S. Pahwa); Department of Biomedical Engineering, University of Miami, Miami, Florida (E.C.W., F.E.T.); University of Miami Miller School of Medicine, Miami, Florida (V.S.S.); Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida (M.E.H.); Department of Public Health, University of Miami, Miami, Florida (V.S.S.); Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York (J.M.C., D.B., P.D., F.K.); Department of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York (F.K.); Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida (A.C.); and Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, New York (J.M.C., D.B., P.D., F.K.).
出版信息
J Occup Environ Med. 2024 Feb 1;66(2):e48-e53. doi: 10.1097/JOM.0000000000003014. Epub 2023 Nov 22.
OBJECTIVE
The effect of stress on vaccine-induced humoral immunity and therapeutic interventions to mitigate pandemic-related stress remain underexplored.
METHOD
Participants in a longitudinal cohort study ( n = 189) completed a validated measure, GAD-7, and 10-instrument stress measure to assess stress and anxiety after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Serum was collected to obtain SARS-CoV-2 antibody titer levels.
RESULTS
Participants experienced increased stress due to the SARS-CoV-2 pandemic with a positive correlation between GAD-7 scores and peak antibody titers overall; however, there was a negative association with scores commensurate with severe anxiety. Health care workers and younger participants were more significantly affected by anxiety.
CONCLUSIONS
Mild anxiety levels may have immune-enhancing effects, whereas severe anxiety may cause antibody generation reduction. Mental health-focused interventions are imperative for younger adults and health care workers. Young adults may be more resilient to increased stress levels.
目的
压力对疫苗诱导的体液免疫的影响以及减轻大流行相关压力的治疗干预措施仍未得到充分探索。
方法
一项纵向队列研究的参与者（n=189）完成了一项经过验证的 GAD-7 量表和 10 项压力量表，以评估在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）接种后出现的压力和焦虑。采集血清以获得 SARS-CoV-2 抗体滴度水平。
结果
由于 SARS-CoV-2 大流行，参与者经历了更多的压力，GAD-7 评分与总体峰值抗体滴度呈正相关；然而，与严重焦虑程度相当的评分呈负相关。医护人员和年轻参与者受到焦虑的影响更为显著。
结论
轻度焦虑水平可能具有免疫增强作用，而严重焦虑可能导致抗体生成减少。针对年轻人和医护人员的心理健康干预措施至关重要。年轻人可能对压力水平的增加更有弹性。
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