Clinical Laboratory, Huzhou Nanxun District Hospital of Traditional Chinese Medicine, Huzhou, China.
Department of Gynaecology and Obstetrics, Huzhou Nanxun District People's Hospital, Huzhou, China.
J Obstet Gynaecol. 2023 Dec;43(2):2286319. doi: 10.1080/01443615.2023.2286319. Epub 2023 Nov 28.
To evaluate the value of the platelet-to-lymphocyte ratio (PLR) in predicting preeclampsia (PE) in pregnant women.
PubMed, EMBASE and Web of Science databases were searched for observational studies (cohort, case-control or cross-sectional) that reported pre-treatment maternal PLR values in women with and without PE. The analysis was done using a random effects model. Pooled effect sizes were reported as weighted mean difference (WMD) with 95% confidence intervals (CIs). Newcastle-Ottawa Scale (NOS) was used to evaluate the risk of bias.
Twenty-five studies with 7755 patients were included in this meta-analysis. PLR was comparable in patients with PE and healthy pregnant women (WMD -2.97; 95% CI: -11.95 to 6.02; = 16). Patients with mild (WMD -3.00; 95% CI: -17.40 to 11.41; = 12) and severe PE (WMD -5.77; 95% CI: -25.48 to 13.94; = 14) had statistically similar PLR, compared to healthy controls.
Our findings show similar PLR in PE and healthy pregnancies. PLR, therefore, may not be used to differentiate between PE and normal pregnancy or for assessing the severity of PE. The majority of included studies were case-control, potentially introducing bias, and we identified evidence of publication bias as well.
评估血小板与淋巴细胞比值（PLR）在预测孕妇子痫前期（PE）中的价值。
检索 PubMed、EMBASE 和 Web of Science 数据库中报道了有或无 PE 的孕妇治疗前母体 PLR 值的观察性研究（队列、病例对照或横断面研究）。采用随机效应模型进行分析。汇总效应大小以加权均数差（WMD）和 95%置信区间（CI）表示。采用纽卡斯尔-渥太华量表（NOS）评估偏倚风险。
共有 25 项研究，7755 例患者纳入荟萃分析。PE 患者和健康孕妇的 PLR 无差异（WMD-2.97；95%CI：-11.95 至 6.02； = 16）。轻度 PE 患者（WMD-3.00；95%CI：-17.40 至 11.41； = 12）和重度 PE 患者（WMD-5.77；95%CI：-25.48 至 13.94； = 14）的 PLR 与健康对照组相比也无统计学差异。
我们的研究结果表明，PE 与健康妊娠的 PLR 相似。因此，PLR 可能不能用于区分 PE 与正常妊娠或评估 PE 的严重程度。纳入的大多数研究为病例对照研究，可能存在偏倚，且我们还发现存在发表偏倚的证据。
