Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
J Mol Med (Berl). 2024 Feb;102(2):149-165. doi: 10.1007/s00109-023-02391-8. Epub 2023 Nov 28.
Sphingolipids (SLs) are vital constituents of the plasma membrane of animal cells and concurrently regulate numerous cellular processes. An escalating number of research have evinced that SLs assume a crucial part in the progression of tissue fibrosis, a condition for which no efficacious cure exists as of now. Cardiac fibrosis, and in particular, atrial fibrosis, is a key factor in the emergence of atrial fibrillation (AF). AF has become one of the most widespread cardiac arrhythmias globally, with its incidence continuing to mount, thereby propelling it to the status of a major public health concern. This review expounds on the structure and biosynthesis pathways of several pivotal SLs, the pathophysiological mechanisms of AF, and the function of SLs in cardiac fibrosis. Delving into the influence of sphingolipid levels in the alleviation of cardiac fibrosis offers innovative therapeutic strategies to address cardiac fibrosis and AF.
鞘脂类（SLs）是动物细胞膜的重要组成部分，同时调节着众多细胞过程。越来越多的研究表明，SLs 在组织纤维化的进展中起着关键作用，而目前尚无有效的治疗方法。心脏纤维化，特别是心房纤维化，是心房颤动（AF）出现的关键因素。AF 已成为全球最普遍的心律失常之一，其发病率持续上升，因此成为一个主要的公共卫生关注点。这篇综述阐述了几种关键 SLs 的结构和生物合成途径、AF 的病理生理机制以及 SLs 在心脏纤维化中的功能。深入研究鞘脂水平对心脏纤维化的缓解作用，为解决心脏纤维化和 AF 提供了创新的治疗策略。
