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预期寿命的增长源于改善男男性行为人群中黑人和白人男性的艾滋病毒护理水平。

Projected Life Expectancy Gains From Improvements in HIV Care in Black and White Men Who Have Sex With Men.

机构信息

Medical Practice Evaluation Center (MPEC), Massachusetts General Hospital, Boston.

Harvard Medical School, Boston, Massachusetts.

出版信息

JAMA Netw Open. 2023 Nov 1;6(11):e2344385. doi: 10.1001/jamanetworkopen.2023.44385.

DOI:10.1001/jamanetworkopen.2023.44385
PMID:38015507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10685884/
Abstract

IMPORTANCE

Substantial racial inequities exist across the HIV care continuum between non-Hispanic Black and White men who have sex with men (MSM) in the US.

OBJECTIVES

To project years of life gained (YLG) with improving the HIV care continuum among Black MSM and White MSM in the US and to determine the outcomes of achieving health equity goals.

DESIGN, SETTING, AND PARTICIPANTS: The Cost-Effectiveness of Preventing AIDS Complications microsimulation model was used and populated with 2021 race-specific data to simulate HIV care among Black MSM and White MSM in the US who have acquired HIV. Analyses were completed from July 2021 to October 2023.

INTERVENTION

The study simulated status quo care using race-specific estimates: age at infection, time to diagnosis, receipt of care, and virologic suppression. The study next projected the outcomes of attaining equity-centered vs non-equity-centered goals by simulating 2 equal improvements in care goals: (10-point increased receipt of care and 5-point increased virologic suppression), 3 equity-centered goals (annual HIV testing, 95% receiving HIV care, and 95% virologic suppression) and lastly, an equitable care continuum that achieves annual HIV testing, 95% receiving care, and 95% virologic suppression in Black MSM and White MSM. One-way and multiway sensitivity and scenario analyses were conducted.

MAIN OUTCOMES AND MEASURES

Mean age at death and YLG.

RESULTS

In the simulated cohort, the mean (SD) age at HIV infection was 27.0 (10.8) years for Black MSM and 35.5 (13.6) years for White MSM. In status quo, mean age at death would be 68.8 years for Black MSM and 75.6 years for White MSM. The equal improvements in care goals would result in 0.5 YLG for Black MSM and 0.5 to 0.9 YLG for White MSM. Achieving any 1 equity-centered goal would result in 0.5 to 1.7 YLG for Black MSM and 0.4 to 1.3 YLG for White MSM. With an equitable care continuum compared with the nationally reported status quo, Black MSM and White MSM would gain 3.5 and 2.1 life-years, respectively. If the status quo HIV testing was every 6 years with 75% retained in care and 75% virologically suppressed, Black MSM would gain 4.2 life-years with an equitable care continuum.

CONCLUSIONS AND RELEVANCE

In this simulation modeling study of HIV care goals, equal improvements in HIV care for Black and White MSM maintained or worsened inequities. These results suggest that equity-centered goals for the HIV care continuum are critical to mitigate long-standing inequities in HIV outcomes.

摘要

重要性

在美国,非裔美国男性和白人男性性行为者(MSM)的艾滋病毒护理连续体中存在着实质性的种族不平等。

目的

预测通过改善美国黑人 MSM 和白人 MSM 的艾滋病毒护理连续体,黑人 MSM 和白人 MSM 每年可获得的寿命(YLG),并确定实现健康公平目标的结果。

设计、地点和参与者:使用预防艾滋病并发症成本效益微模拟模型进行模拟,并使用 2021 年特定种族的数据进行人口统计,以模拟在美国获得艾滋病毒的黑人 MSM 和白人 MSM 的艾滋病毒护理。分析于 2021 年 7 月至 2023 年 10 月完成。

干预措施

该研究使用特定种族的估计值模拟了现状护理:感染年龄、诊断时间、获得护理和病毒学抑制。该研究通过模拟以下两个以公平为中心的护理目标的结果来预测达到以公平为中心的目标与非公平为中心的目标的结果:(增加 10 分的护理接受率和增加 5 分的病毒学抑制率)、三个以公平为中心的目标(每年进行艾滋病毒检测、95%接受艾滋病毒护理和 95%的病毒学抑制)以及最后,实现年度艾滋病毒检测、95%接受护理和 95%病毒学抑制的公平护理连续体在黑人 MSM 和白人 MSM 中。进行了单向和多向敏感性和情景分析。

主要结果和测量

平均死亡年龄和 YLG。

结果

在模拟队列中,黑人 MSM 的平均(SD)感染年龄为 27.0(10.8)岁,白人 MSM 为 35.5(13.6)岁。在现状下,黑人 MSM 的平均死亡年龄将为 68.8 岁,白人 MSM 为 75.6 岁。护理目标的平等改善将使黑人 MSM 的 YLG 增加 0.5 年,而白人 MSM 的 YLG 增加 0.5 至 0.9 年。实现任何一个以公平为中心的目标将使黑人 MSM 的 YLG 增加 0.5 至 1.7 年,而白人 MSM 的 YLG 增加 0.4 至 1.3 年。与全国报告的现状相比,黑人 MSM 和白人 MSM 的预期寿命将分别延长 3.5 和 2.1 年。如果现状的艾滋病毒检测是每 6 年进行一次,有 75%的人保留在护理中,有 75%的人病毒学上得到抑制,那么黑人 MSM 将通过公平的护理连续体获得 4.2 年的预期寿命。

结论和相关性

在这项关于艾滋病毒护理目标的模拟建模研究中,黑人 MSM 和白人 MSM 的艾滋病毒护理平等改善维持或加剧了不平等。这些结果表明,艾滋病毒护理连续体以公平为中心的目标对于减轻艾滋病毒结果的长期不平等至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/191d/10685884/dd80c5c9e6ac/jamanetwopen-e2344385-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/191d/10685884/ce22b8ca2be9/jamanetwopen-e2344385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/191d/10685884/5a5a340044c4/jamanetwopen-e2344385-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/191d/10685884/dd80c5c9e6ac/jamanetwopen-e2344385-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/191d/10685884/ce22b8ca2be9/jamanetwopen-e2344385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/191d/10685884/5a5a340044c4/jamanetwopen-e2344385-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/191d/10685884/dd80c5c9e6ac/jamanetwopen-e2344385-g003.jpg

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