Strelkov R B, Chizhov A Ia, Il'ina A I, Kuznetsova L E, Pines E V
Vopr Onkol. 1979;25(6):3-6.
Studies on volunteers have shown that the gas hypoxic mixture containing 10% of oxygen and 90% of nitrogen (GHM-10) renders a protective action on the genetic apparatus of human skin cells but provides no protection of the peripheral blood leucocytes, which show the identical character of metabolic processes as neoplastic cells. Under clinically performed distant x-ray therapy for breast cancer the inhaling of GHM-10 was found to render the antiradiation protective action on different normal tissues (skin, subcellular connective tissue, muscle tissue, mammary gland tissue), but it fails to protect the tumor tissue and regional lymph nodes involved. The clinical observations were supported by pathomorphological examination of the operation material.
对志愿者的研究表明，含有10%氧气和90%氮气的气体低氧混合物（GHM - 10）对人体皮肤细胞的遗传机制具有保护作用，但对外周血白细胞没有保护作用，外周血白细胞与肿瘤细胞具有相同的代谢过程特征。在乳腺癌的临床远距离X射线治疗中，发现吸入GHM - 10对不同的正常组织（皮肤、亚细胞结缔组织、肌肉组织、乳腺组织）具有抗辐射保护作用，但未能保护肿瘤组织及受累的区域淋巴结。手术材料的病理形态学检查支持了这些临床观察结果。
