Siubaev R D, Shvarts G Ia
Biull Eksp Biol Med. 1986 Dec;102(12):733-5.
It has been demonstrated on isolated guinea-pig ileum and rats that nonsteroid antiinflammatory drugs (acetylsalicylic acid, ibuprofen, diclofenac sodium, butadione, and indomethacin) antagonized spasmogenic and inflammatory effects of sodium arachidonate, but not of other mediators of inflammation such as histamine, serotonin, bradykinin and PGE2. "Antiarachidonic" potency of nonsteroid antiinflammatory drugs correlated well with their antiinflammatory activity and their ability to inhibit endogenous PG biosynthesis. This method determining the antagonism to arachidonic acid effects in simple in vitro and in vivo models can be useful for screening nonsteroid antiinflammatory drug potential.
在离体豚鼠回肠和大鼠身上已证实，非甾体抗炎药（乙酰水杨酸、布洛芬、双氯芬酸钠、布他酮和吲哚美辛）可拮抗花生四烯酸钠的致痉挛和炎症作用，但对组胺、5-羟色胺、缓激肽和前列腺素E2等其他炎症介质则无此作用。非甾体抗炎药的“抗花生四烯酸”效力与其抗炎活性及其抑制内源性前列腺素生物合成的能力密切相关。这种在简单的体外和体内模型中测定对花生四烯酸作用的拮抗作用的方法，可用于筛选非甾体抗炎药的潜力。
