体外反搏增强可增加冠状动脉微血管病患者的冠状动脉血流储备。
Enhanced external counterpulsation increases coronary flow reserve in coronary microvascular disease.
机构信息
From the Department of Cardiology, The first hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.
出版信息
Saudi Med J. 2023 Dec;44(12):1277-1282. doi: 10.15537/smj.2023.44.12.20230427.
OBJECTIVES
To investigates the outcomes of enhanced external counterpulsation (EECP) among coronary microvascular disease (CMD) patients.
METHODS
Coronary microvascular disease patients were separated into the EECP (n=41) and control cohorts (n=42). Prior to and following the 4-week EECP program, coronary flow reserve (CFR) was recorded using transthoracic Doppler echocardiography. The serum endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) contents were analyzed by ELISA. Quality of life (QoL) was assessed by the Seattle Angina Questionnaire (SAQ) and the Canadian Cardiovascular Society (CCS) angina class.
RESULTS
After four weeks, CFR was substantially enhanced in the EECP versus control cohort (<0.05). Endothelin-1 was strongly diminished whereas eNOS was considerably upregulated in the EECP cohort. EECP also enhanced patients' SAQ scores and decreased the CCS angina class.
CONCLUSION
Enhanced external counterpulsation may improve CFR and enhance the CMD patient QoL.
目的
研究增强型体外反搏（EECP）对冠状动脉微血管疾病（CMD）患者的疗效。
方法
将 CMD 患者分为 EECP 组（n=41）和对照组（n=42）。在 EECP 治疗前和治疗 4 周后，采用经胸多普勒超声心动图记录冠状动脉血流储备（CFR）。采用 ELISA 法检测血清内皮型一氧化氮合酶（eNOS）和内皮素-1（ET-1）含量。采用西雅图心绞痛问卷（SAQ）和加拿大心血管学会（CCS）心绞痛分级评估生活质量（QoL）。
结果
4 周后，EECP 组的 CFR 明显高于对照组（<0.05）。EECP 组的内皮素-1明显降低，而 eNOS 明显升高。EECP 还可提高患者的 SAQ 评分，降低 CCS 心绞痛分级。
结论
增强型体外反搏可改善 CFR，提高 CMD 患者的 QoL。
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