Zhao Shangping, Chen Hong, Shi Xiaoying, Tan Qiling, Gu Bo
West China School of Nursing, Sichuan University/Ward of Nephrology and Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
J Thromb Thrombolysis. 2024 Feb;57(2):278-284. doi: 10.1007/s11239-023-02911-w. Epub 2023 Nov 28.
To investigate the incidence and explore the risk factors of venous thromboembolism (VTE) within 6 months after kidney transplantation. Total of 331 kidney transplant recipients were assessed by venous ultrasonography for VTE at 14 days, 1 month, 3 months, and 6 months post-transplantation. Cox forward regression were used to identify the independent risk factors of VTE. This study registration number is ChiCTR1900020567 and the date of registration was 2019/01/08. The cumulative incidence of VTE was 2.72% (9/331) within 6 months after transplant. 77.8% (7/9) of VTEs occurred in the first 3 months post-transplantation. 88.9% (1/9) of VTEs were asymptomatic, 66.7% (6/9) of VTEs were mural thromboses and in the right lower extremity. Central vena catheterization (HR = 6.94) and severe pulmonary disease (including pneumonia) (HR = 57.35) were the risk factors for VTE in kidney transplantation recipients. KT patients are the high risk population of VTE. Future interventions should be strengthen for KT patients to receive a minimum of 3-month of precautionary measures for VTE, including infection prevention, and strengthening thromboprophylaxis on the CVC or transplanted side of lower extremity.
为调查肾移植后6个月内静脉血栓栓塞症（VTE）的发生率并探索其危险因素。对331例肾移植受者在移植后14天、1个月、3个月和6个月时进行静脉超声检查以评估VTE情况。采用Cox向前回归分析确定VTE的独立危险因素。本研究注册号为ChiCTR1900020567，注册日期为2019年1月8日。移植后6个月内VTE的累积发生率为2.72%（9/331）。77.8%（7/9）的VTE发生在移植后的前3个月。88.9%（1/9）的VTE无症状，66.7%（6/9）的VTE为壁血栓且位于右下肢。中心静脉置管（HR = 6.94）和严重肺部疾病（包括肺炎）（HR = 57.35）是肾移植受者发生VTE的危险因素。肾移植患者是VTE的高危人群。未来应加强对肾移植患者的干预，使其至少接受3个月的VTE预防措施，包括预防感染以及加强中心静脉导管或下肢移植侧的血栓预防。
