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肾移植受者中与巨细胞病毒(CMV)相关的血栓形成

Thrombosis Associated With Cytomegalovirus (CMV) in a Kidney Transplant Recipient.

作者信息

Wang Lin, Hsu Young, Sharma Neeraj

机构信息

Nephrology, University of Southern California, Los Angeles, USA.

Internal Medicine, Keck School of Medicine, Los Angeles, USA.

出版信息

Cureus. 2021 Sep 5;13(9):e17745. doi: 10.7759/cureus.17745. eCollection 2021 Sep.

DOI:10.7759/cureus.17745
PMID:34659958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8492551/
Abstract

Cytomegalovirus (CMV) infection is a common infectious complication after kidney transplantation. Indirect effects of CMV infection include an increased risk of secondary infections, increased risk of acute rejection, and chronic allograft dysfunction. However, it is not well known that CMV may also increase the risk of venous and arterial thrombosis. Here, we present a case of acute deep venous thromboembolism associated with acute CMV disease in a kidney transplant recipient. We also performed a literature review of cytomegalovirus-associated thrombosis in immunocompromised individuals.

摘要

巨细胞病毒(CMV)感染是肾移植后常见的感染性并发症。CMV感染的间接影响包括继发感染风险增加、急性排斥反应风险增加以及慢性移植肾失功。然而,CMV也可能增加静脉和动脉血栓形成的风险,这一点尚不为人熟知。在此,我们报告一例肾移植受者发生的与急性CMV疾病相关的急性深静脉血栓栓塞病例。我们还对免疫功能低下个体中与巨细胞病毒相关的血栓形成进行了文献综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333c/8492551/6aa16275101c/cureus-0013-00000017745-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333c/8492551/6aa16275101c/cureus-0013-00000017745-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333c/8492551/6aa16275101c/cureus-0013-00000017745-i01.jpg

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Risk Factors for Erythrocytosis in Renal Transplantation: Is Ganciclovir Therapy One of Them?肾移植后红细胞增多症的危险因素:更昔洛韦治疗是其中之一吗?
Ann Transplant. 2022 Aug 19;27:e936814. doi: 10.12659/AOT.936814.

本文引用的文献

1
Cytomegalovirus-Associated Venous and Arterial Thrombotic Disease.巨细胞病毒相关的静脉和动脉血栓性疾病
Cureus. 2020 Dec 18;12(12):e12161. doi: 10.7759/cureus.12161.
2
Recurrence of CMV Infection and the Effect of Prolonged Antivirals in Organ Transplant Recipients.器官移植受者巨细胞病毒感染的复发和抗病毒药物延长治疗的效果。
Transplantation. 2017 Jun;101(6):1449-1454. doi: 10.1097/TP.0000000000001338.
3
Hypercoagulability in Kidney Transplant Recipients.肾移植受者的高凝状态。
Transplantation. 2016 Apr;100(4):719-26. doi: 10.1097/TP.0000000000000887.
4
Accuracy of Inpatient International Classification of Diseases, Ninth Revision, Clinical Modification Coding for Cytomegalovirus After Kidney Transplantation.肾移植后巨细胞病毒感染的住院患者国际疾病分类第九版临床修订版编码准确性
Transplant Proc. 2015 Jul-Aug;47(6):1772-6. doi: 10.1016/j.transproceed.2015.04.087.
5
Incidence of cytomegalovirus-associated thrombosis and its risk factors: a case-control study.巨细胞病毒相关性血栓形成的发生率及其危险因素:一项病例对照研究。
Thromb Res. 2010 Dec;126(6):e439-43. doi: 10.1016/j.thromres.2010.09.006.
6
Possible contribution of cytomegalovirus infection to the high risk of (recurrent) venous thrombosis after renal transplantation.巨细胞病毒感染对肾移植后(复发性)静脉血栓形成高风险的可能影响。
Thromb Haemost. 2008 Jan;99(1):127-32. doi: 10.1160/TH07-05-0340.
7
Effects of human cytomegalovirus infection on the coagulation system.人类巨细胞病毒感染对凝血系统的影响。
Thromb Haemost. 2005 Mar;93(3):403-10. doi: 10.1160/TH04-08-0523.
8
Hypercoagulability in renal transplant recipients. Identifying patients at risk of renal allograft thrombosis and evaluating strategies for prevention.肾移植受者的高凝状态。识别有肾移植血栓形成风险的患者并评估预防策略。
Am J Cardiovasc Drugs. 2004;4(3):139-49. doi: 10.2165/00129784-200404030-00001.
9
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10
Acquired hypercoagulable state in renal transplant recipients.肾移植受者获得性高凝状态
Thromb Haemost. 2004 Apr;91(4):646-54. doi: 10.1160/TH03-09-0568.