非侵入性迷走神经刺激：炎症性肠病治疗的未来？
Non-invasive vagus nerve stimulation: the future of inflammatory bowel disease treatment?
作者信息
Bonaz Bruno
机构信息
Service d'Hépato-Gastroentérologie, Grenoble Institut Neurosciences, Université Grenoble Alpes, Grenoble, France.
出版信息
Bioelectron Med. 2023 Nov 29;9(1):26. doi: 10.1186/s42234-023-00129-y.
Abstract
The vagus nerve regulates inflammation and cytokine release through the inflammatory reflex. Recent pilot clinical trials using implantable bioelectronic devices have demonstrated the efficacy of vagus nerve stimulation (VNS) in adult patients with inflammatory bowel diseases (IBD) as an alternative to drug treatments. However, the use of non-invasive VNS should be of interest in adults with IBD and even more in pediatric IBD. In this issue of Bioelectronic Medicine, Sahn et al. report that non-invasive transcutaneous auricular VNS attenuated signs and symptoms in a pediatric cohort with mild to moderate IBD thus opening new therapeutic avenues in the management of pediatric but also adult IBD patients.
摘要
迷走神经通过炎症反射调节炎症和细胞因子释放。最近使用可植入生物电子设备的初步临床试验已证明，迷走神经刺激（VNS）对患有炎症性肠病（IBD）的成年患者有效，可作为药物治疗的替代方法。然而，非侵入性VNS的应用对于成年IBD患者应具有吸引力，对儿科IBD患者更具吸引力。在本期《生物电子医学》中，萨恩等人报告称，非侵入性经皮耳迷走神经刺激减轻了轻度至中度IBD儿科队列中的体征和症状，从而为儿科以及成年IBD患者的治疗开辟了新途径。
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