Department of Sports Medicine, SportsValley, Hospital Gelderse Vallei, Willy Brandtlaan 10, 6716 RP, Ede, The Netherlands.
Division of Human Nutrition and Health, Wageningen University & Research (WUR), Wageningen, The Netherlands.
Trials. 2023 Nov 28;24(1):768. doi: 10.1186/s13063-023-07783-2.
Patellar tendinopathy (PT) is a common problem in jumping athletes. Management can be challenging and treatment outcome is not always successful. In combination with tendon loading exercises, hydrolyzed collagen/vitamin C supplementation appears to have a promising effect on the recovery of tendinopathy. The aim of this study is to evaluate whether the use of oral supplementation of hydrolyzed collagen and vitamin C in combination with progressive tendon loading exercises (PTLE) is superior to PTLE and placebo on VISA-P score (which rates pain, function, sports participation) after 24 weeks for athletes with PT.
The JUMPFOOD study is a double-blinded, two-armed randomized controlled trial, in which the effectiveness of oral supplementation of hydrolyzed collagen/vitamin C combined with PTLE compared to PTLE with placebo on pain and recovery of function in athletes with PT will be investigated. Seventy-six athletes aged 16-40 years, with symptoms of PT for at least 12 weeks, who play sports at least once a week will be included. All participants will receive education, advice with regard to load management and a PTLE program according to the Dutch guidelines for anterior knee pain. In addition, the intervention group will receive daily 10 g hydrolyzed collagen and 40 mg vitamin C supplementation for 24 weeks whereas the control group receives 10 g maltodextrin placebo supplementation. Measurements will take place at baseline and at 12 and 24 weeks' follow-up. Primary outcome is the VISA-P score, which evaluates pain, function, and sports participation. For secondary outcome measures, data with regard to pain during functional tests, flexibility measurements, blood withdrawals, imaging characteristics of the tendon, and health questionnaires will be collected. During the follow-up period, participants will register sports participation, amount of training and tendon load, pain during sports, co-medication, and side-effects in a digital weekly diary.
The JUMPFOOD study is the first large RCT to study the effectiveness of hydrolyzed collagen/vitamin C supplementation in combination with the PTLE program in athletes with patellar tendinopathy. If supplementation of collagen/vitamin C appears to be effective, this treatment can be implemented in daily sports medicine practice to improve the treatment outcome of patients with PT.
ClinicalTrials.gov NCT05407194. Registered on 7 June 2022.
髌腱病（PT）是跳跃运动员中常见的问题。这种疾病的治疗具有挑战性，治疗效果并不总是成功。结合肌腱负荷练习，水解胶原蛋白/维生素 C 补充剂似乎对腱病的恢复有积极作用。本研究旨在评估在 24 周时，与单独进行肌腱负荷练习（PTLE）和安慰剂相比，口服水解胶原蛋白和维生素 C 补充剂联合 PTLE 是否能在 VISA-P 评分（评估疼痛、功能、运动参与度）上为髌腱病运动员带来更好的效果。
JUMPFOOD 研究是一项双盲、双臂随机对照试验，旨在研究口服水解胶原蛋白/维生素 C 补充剂联合 PTLE 与单独进行 PTLE 加安慰剂相比，对髌腱病运动员疼痛和功能恢复的影响。将纳入 76 名年龄在 16-40 岁之间、有至少 12 周髌腱病症状、每周至少运动一次的运动员。所有参与者都将接受教育、负荷管理方面的建议，并根据荷兰膝关节前侧疼痛指南进行 PTLE 方案。此外，干预组将在 24 周内每天补充 10g 水解胶原蛋白和 40mg 维生素 C，而对照组则补充 10g 麦芽糊精安慰剂。测量将在基线和 12 周及 24 周的随访时进行。主要结局指标是 VISA-P 评分，用于评估疼痛、功能和运动参与度。次要结局指标包括功能测试、柔韧性测量、血液采集、肌腱的影像学特征和健康问卷的数据。在随访期间，参与者将在数字每周日记中记录运动参与度、训练和肌腱负荷量、运动时的疼痛、合并用药和副作用。
JUMPFOOD 研究是第一项研究水解胶原蛋白/维生素 C 补充剂联合 PTLE 方案在髌腱病运动员中的有效性的大型 RCT。如果胶原蛋白/维生素 C 补充剂有效，这种治疗方法可以在日常运动医学实践中实施，以提高髌腱病患者的治疗效果。
ClinicalTrials.gov NCT05407194。注册于 2022 年 6 月 7 日。
