Halal Research Center of IRI, FDA, Tehran, Iran.
Department of Cellular and molecular Nutrition, School of Nutritional sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2020 Jul;34(7):1599-1608. doi: 10.1002/ptr.6640. Epub 2020 Feb 19.
The aim of the study was to investigate the impact of supplementation with flaxseed on plasma lipoprotein(a) [Lp(a)] levels through a systematic review and meta-analysis of eligible randomized placebo-controlled trials. PubMed, Scopus, Cochrane Library, and ISI Web of Science were searched for randomized controlled trials (RCTs) which have been published up to November 2019. RCTs that investigated the effect of flaxseed supplementation on plasma Lp(a) levels in adults were included for final analysis. The random effects model was used for calculating the overall effects. Meta-analysis of 7 selected RCTs with 629 individuals showed significant lowering effect of flaxseed supplementation on Lp(a) (MD -2.06 mg/dl; 95% CI: -3.846, -0.274, p = .024), without considerable heterogeneity between studies (p = .986, I = 0%). Subgroup analysis also revealed that longer duration only showed significant lowering effect of flaxseed supplementation on Lp(a). This meta-analysis has shown that flaxseed supplementation might significantly decrease plasma Lp(a) levels. Future well-designed and long-term clinical trials are required to confirm these results.
本研究旨在通过对合格的随机安慰剂对照试验进行系统评价和荟萃分析，研究亚麻籽补充剂对血浆脂蛋白（a）[Lp（a）]水平的影响。检索了截至 2019 年 11 月发表的随机对照试验（RCT）的 PubMed、Scopus、Cochrane 图书馆和 ISI Web of Science。纳入了最终分析的 RCT，这些 RCT 研究了亚麻籽补充剂对成年人血浆 Lp（a）水平的影响。使用随机效应模型计算总体效应。对 7 项具有 629 名个体的入选 RCT 进行荟萃分析表明，亚麻籽补充剂对 Lp（a）有显著的降低作用（MD-2.06mg/dl；95%CI：-3.846，-0.274，p=0.024），研究之间无明显异质性（p=0.986，I=0%）。亚组分析还表明，较长的持续时间仅显示亚麻籽补充剂对 Lp（a）有显著的降低作用。这项荟萃分析表明，亚麻籽补充剂可能显著降低血浆 Lp（a）水平。需要进一步进行设计良好且长期的临床试验来证实这些结果。
