Department of Physical Activity and Sport Sciences, Faculty of Education and Sport, University of Deusto, Bilbao, Spain.
Department of Radiation Oncology, Group for Radiology and Physical Medicine in Oncology, Cruces University Hospital/Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Am J Clin Oncol. 2024 Apr 1;47(4):161-168. doi: 10.1097/COC.0000000000001070. Epub 2023 Nov 29.
Creatine supplementation is an effective ergogenic nutrient for athletes, as well as for people starting a health or fitness program. Resistance training has previously been identified as an important method of increasing muscle mass and strength, especially in people with cancer to avoid sarcopenia. The potential of creatine supplementation for adaptations produced by resistance training in patients with cancer is still unknown. The primary aim of this study is to evaluate the effectiveness of a supervised resistance training program intervention with and without creatine supplementation in patients with breast cancer.
Is a multicentre, randomized, blind, placebo-controlled study. Patients will be randomly assigned to a control group and 2 experimental groups. The first training resistance group (RG) will perform resistance training, while the second experimental resistance-creatine group will perform the same resistance training as the RG and will also receive a 5 g/d creatine supplementation during the intervention. RG participants will follow the same daily dosing protocol, but in their case, with dextrose/maltodextrin. Resistance training will be a 16-week supervised workout that will consist of a series of resistance exercises (leg press, knee extension, knee bends, chest press, sit-ups, back extensions, pull-ups, and shoulder press) that involve the largest muscle groups, performed 3 times a week on nonconsecutive days. Both the RG and the resistance-creatine group will receive a supplement of soluble protein powder (20 to 30 g) daily.
This intervention will help to better understand the potential of nonpharmacological treatment for improving strength and well-being values in patients with breast cancer with and without creatine supplementation.
肌酸补充剂是运动员和开始健康或健身计划的人的有效运动营养物质。抗阻训练以前被确定为增加肌肉质量和力量的重要方法，尤其是在癌症患者中，以避免肌肉减少症。肌酸补充剂对癌症患者抗阻训练产生的适应性的潜力尚不清楚。本研究的主要目的是评估有监督的抗阻训练计划干预与肌酸补充剂对乳腺癌患者的有效性。
这是一项多中心、随机、双盲、安慰剂对照研究。患者将被随机分配到对照组和 2 个实验组。第一组抗阻训练组（RG）将进行抗阻训练，而第二组抗阻-肌酸组将进行与 RG 相同的抗阻训练，并在干预期间接受 5 克/天的肌酸补充剂。RG 参与者将遵循相同的每日剂量方案，但在他们的情况下，使用葡萄糖/麦芽糊精。抗阻训练将是一个 16 周的监督锻炼，包括一系列抗阻运动（腿推、膝伸、膝弯、卧推、仰卧起坐、背伸展、引体向上和肩推），涉及最大的肌肉群，每周进行 3 次，非连续日进行。RG 和抗阻-肌酸组都将每天补充可溶蛋白粉（20 到 30 克）。
这项干预措施将有助于更好地了解非药物治疗在乳腺癌患者中提高力量和健康相关生活质量的潜力，无论是否补充肌酸。
