Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
BMJ Open. 2019 Sep 20;9(9):e030080. doi: 10.1136/bmjopen-2019-030080.
Creatine supplementation has consistently been demonstrated to augment adaptations in body composition, muscle strength and physical function in a variety of apparently healthy older adults and clinical populations. The effects of creatine supplementation and resistance training in individuals with cancer have yet to be investigated. This study aims to examine the effects of creatine supplementation in conjunction with resistance training on body composition, muscle strength and physical function in prostate cancer patients undergoing androgen deprivation therapy.
This is a randomised, double-blind, placebo-controlled trial designed to examine the effects of creatine supplementation in addition to resistance training in patients with prostate cancer receiving androgen deprivation therapy. Both supplement and placebo groups will receive a 12-week supervised exercise programme comprising resistance training undertaken three times per week. The primary endpoint (fat-free mass) and secondary endpoints (fat mass, per cent body fat, physical fitness, quality of life and blood biomarkers) will be assessed at baseline and immediately following the intervention.
The Human Research Ethics Committee of Edith Cowan University approved this study (ID: 22243 FAIRMAN). If the results of this trial demonstrate that creatine supplementation can augment beneficial adaptations of body composition, physical function and/or psychosocial outcomes to resistance training, this study will provide effect sizes that will inform the design of subsequent definitive randomised controlled trials. The results of this study will be published in peer-reviewed journals and presented at various national and international conferences.
ACTRN12619000099123.
肌酸补充剂已被一致证明可增强各种明显健康的老年人和临床人群的身体成分、肌肉力量和身体功能的适应性。肌酸补充剂和抗阻训练对癌症患者的影响尚未得到研究。本研究旨在探讨肌酸补充剂与抗阻训练联合应用于接受雄激素剥夺治疗的前列腺癌患者对身体成分、肌肉力量和身体功能的影响。
这是一项随机、双盲、安慰剂对照试验，旨在研究肌酸补充剂联合抗阻训练对接受雄激素剥夺治疗的前列腺癌患者的影响。补充剂组和安慰剂组都将接受为期 12 周的监督运动计划，包括每周进行三次抗阻训练。主要终点（去脂体重）和次要终点（脂肪量、体脂百分比、身体适应性、生活质量和血液生物标志物）将在基线和干预后立即进行评估。
伊迪丝·考恩大学人类研究伦理委员会批准了这项研究（ID：22243 FAIRMAN）。如果这项试验的结果表明肌酸补充剂可以增强对阻力训练的身体成分、身体功能和/或心理社会结果的有益适应性，那么这项研究将提供影响大小，为随后的确定性随机对照试验提供设计依据。这项研究的结果将发表在同行评议的期刊上，并在各种国家和国际会议上展示。
ACTRN12619000099123。
