Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran.
Immun Inflamm Dis. 2023 Nov;11(11):e1090. doi: 10.1002/iid3.1090.
Respiratory disease (RD) is one of the most common diseases characterized by lung dysfunction. Many diagnostic mechanisms have been used to identify the pathogenic agents of responsible for RD. Among these, proteomics emerges as a valuable diagnostic method for pinpointing the specific proteins involved in RD pathogenesis. Therefore, in this study, for the first time, we examined the protein markers involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), asthma, bronchiolitis obliterans (BO), and chemical warfare victims exposed to mustard gas, using the proteomics method as a systematic study.
A systematic search was performed up to September 2023 on several databases, including PubMed, Scopus, ISI Web of Science, and Cochrane. In total, selected 4246 articles were for evaluation according to the criteria. Finally, 119 studies were selected for this systematic review.
A total of 13,806 proteins were identified, 6471 in COPD, 1603 in Asthma, 5638 in IPF, three in BO, and 91 in mustard gas exposed victims. Alterations in the expression of these proteins were observed in the respective diseases. After evaluation, the results showed that 31 proteins were found to be shared among all five diseases.
Although these 31 proteins regulate different factors and molecular pathways in all five diseases, they ultimately lead to the regulation of inflammatory pathways. In other words, the expression of some proteins in COPD and mustard-exposed patients increases inflammatory reactions, while in IPF, they cause lung fibrosis. Asthma, causes allergic reactions due to T-cell differentiation toward Th2.
呼吸疾病（RD）是最常见的以肺功能障碍为特征的疾病之一。已经使用了许多诊断机制来识别负责 RD 的致病因子。在这些机制中，蛋白质组学作为一种有价值的诊断方法，可用于确定 RD 发病机制中涉及的特定蛋白质。因此，在这项研究中，我们首次使用蛋白质组学方法作为系统研究，检查慢性阻塞性肺疾病（COPD）、特发性肺纤维化（IPF）、哮喘、闭塞性细支气管炎（BO）和芥子气暴露的化学战受害者发病机制中涉及的蛋白质标志物。
截至 2023 年 9 月，在几个数据库（包括 PubMed、Scopus、ISI Web of Science 和 Cochrane）上进行了系统搜索。根据标准，总共评估了 4246 篇文章。最后，选择了 119 项研究进行这项系统综述。
共鉴定出 13806 种蛋白质，COPD 中有 6471 种，哮喘中有 1603 种，IPF 中有 5638 种，BO 中有 3 种，芥子气暴露受害者中有 91 种。这些蛋白质的表达在各自的疾病中发生了改变。经过评估，结果表明，在所有五种疾病中发现了 31 种共享的蛋白质。
尽管这 31 种蛋白质在所有五种疾病中调节不同的因素和分子途径，但它们最终都导致了炎症途径的调节。换句话说，COPD 和芥子气暴露患者中一些蛋白质的表达增加了炎症反应，而在 IPF 中，它们导致肺纤维化。哮喘会导致 T 细胞向 Th2 分化引起过敏反应。
